Sr.Data Scientist, Cheminformatics

Cambridge, MA, United States

Why join us?

FogPharma is a biopharmaceutical company pioneering the discovery and development of Helicon therapeutics, which are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, FogPharma is poised to revolutionize the medical possibilities for patients by precisely drugging intracellular targets long understood to be significant drivers of disease but never before drugged due to the limitations of existing drug modalities to act within the cell.

FOG-001, the company's first-in-class TCF-blocking β-catenin inhibitor, is being evaluated in a Phase 1/2 study for patients with advanced solid tumors, including colorectal cancer. FogPharma is fully leveraging the unprecedented potential Helicons present by deploying proprietary, custom-built machine learning and computational methods as part of its discovery and development process. FogPharma has raised more than $500 million to date from leading life sciences investors. FogPharma is headquartered in Cambridge, Mass.

What's the opportunity?

We seek a highly talented and motivated Senior Cheminformatician/Data Scientist to support the platform discovery engine for HeliconTM peptide drugs. Reporting to the Associate Director of Cheminformatics, the candidate will work collaboratively with biologists and chemists, leveraging skills in cheminformatics and data science to enable hypothesis generation and data insights for advancing Fog preclinical drug discovery.

You'll be part of a data science team that is a central pillar of FogPharma's innovative discovery platform and pipelines targeting "undruggable" genes of major therapeutic interest to patients. Our data science team is an integrated team ranging from computational biology, bioinformatics, computational drug discovery, research informatics and data engineering. We work at the interface of chemistry, biology, clinical and computational sciences, and are responsible for all aspects of data science from building the discovery pipeline to supporting and developing our discovery platform.

Responsibilities

* Provide scientific leadership and (chem)informatics expertise towards, but not limited to, hit identification, targeted screening library designs, hit prioritization, hit-to-lead progression using multi-objective optimization, new drug-target assessments and advancing drug-pipeline projects towards clinic

* Analyze peptide/chemical structure and property space to identify patterns / gaps & inform designs

* Adapt and implement data analytics and machine learning techniques towards predictive models of HeliconTM properties

* Contribute to implementation and development of cheminformatics and research informatics systems and tools for Fog

* Work with IT and data engineering to enable enterprise-level cheminformatics solutions

What you'll need to be successful:

* MS or PhD in Cheminformatics, Computational Chemistry or Computational Biology, Chemistry, Biophysics, Macromolecular sciences, Computer Science, or related scientific field with 3+ years of experience within the pharmaceutical or biotechnology field

* Demonstrated expertise with cheminformatics (e.g. RDKit, ICM, OEChem) and data science toolkits/libraries (e.g. Pandas, Scikit-Learn, and Numpy)

* Demonstrated understanding of critical assessment of molecule-property data and predictive model quality

* Demonstrated expertise in data analytics and solid grasp of statistical principles

* Experience with data visualization techniques and exploration tools (e.g Vortex, Spotfire, Datawarrior, DataGrok)

* Strong scientific programming skills (Python). Familiarity with modern pipeline tools is a plus.

* Excellent communication and collaboration skills that contribute to and inspire a vibrant community of drug hunters

* Experience with (chem)informatics analyses of peptides, machine learning, databases/enterprise informatics systems (e.g. Dotmatics), or cloud computing environments (e.g. Google, AWS, Azure) is a plus

Core Values

FogPharma is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

* Creative. We are creating a whole new class of medicine requiring creativity to solve challenges as they arise, which we have successfully done since the inception of the company.

* Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.

* Execution-oriented. As we begin clinical development and large-scale manufacturing, the team is balancing creativity and nimbleness with relentless, rigorous and flawless execution.

* Humble. We fully appreciate that science and technology and policy are in flux, and we balance deep experience with humility to ask fundamental questions and seek newly available solutions.

As an equal opportunity employer, Fog values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive | Cambridge, MA 02140 | www.fogpharma.com