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Biogen Idec
Cambridge, MA, United States
Company Description Job Description About This Role New drugs are discovered through creative design and pioneering medicinal chemistry. In this role, you will leverage your modeling skills and knowledge of computational chemistry to support the design and prioritization of new small molecules aimed to treat neurological and rare diseases. You w
Job Source: Biogen IdecKEMIO Consulting
Boston, MA, United States
Associate Director or Director, Cheminformatics Cambridge, Massachusetts **ONSITE** Generative AI, Drug Discovery, Pharmaceutical, Machine Learning, Artificial Intelligence KEMIO are representing a global pharmaceutical company in Cambridge, MA, who are building cheminformatics capabilities at their R&D site in Massachusetts. This medium sized
Job Source: KEMIO ConsultingX4 Life Sciences
Boston, MA, United States
Your Role: As a Senior Application and Discovery Scientist, you will join the product management team for our AI, Cheminformatics, and automation drug discovery products. You will play a crucial role in developing AI-enabled software and a robotics ecosystem for drug discovery. Key Responsibilities: Serve as a superuser of our AI/Cheminformatics so
Job Source: X4 Life SciencesX4lifesciences
Boston, MA, United States
Your Role: As a Senior Application and Discovery Scientist, you will join the product management team for our AI, Cheminformatics, and automation drug discovery products. You will play a crucial role in developing AI-enabled software and a robotics ecosystem for drug discovery. Key Responsibilities: Serve as a superuser of our AI/Cheminformatics so
Job Source: X4lifesciencesAffinity Executive Search
Woburn, MA, United States
My client leverages AI, robotics, and cheminformatics to solve drug discovery issues, and they seek a Senior Applications Scientist. YOU will partner with industry leaders and contribute to a cutting edge group. YOU will make an impact in drug discovery and development. Responsibilities: 1. Serve as an expert for the software product and provi
Job Source: Affinity Executive SearchDana-Farber Cancer Institute
Boston, MA, United States
The Computational Chemistry Core at Dana-Farber Cancer Institute combines structure-based drug design, computational biology, cheminformatics to support chemical biology and drug discovery programs. We are seeking a highly motivated individual to join the team as a scientist I who will work on computational molecular modeling projects in the Center
Job Source: Dana-Farber Cancer InstituteBiogen
Cambridge, MA, United States
Job Description About This Role New drugs are discovered through creative design and pioneering medicinal chemistry. In this role, you will leverage your modeling skills and knowledge of computational chemistry to support the design and prioritization of new small molecules aimed to treat neurological and rare diseases. You will be expected to wo
Job Source: BiogenFogPharma
Cambridge, MA, United States
Why join us? FogPharma is a biopharmaceutical company pioneering the discovery and development of Helicon therapeutics, which are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, FogPharma is poised to revolutionize the medical possibilities for patients by
Job Source: FogPharmaCambridge, MA, United States
Scientist, Computational Chemistry/Cheminformatics Full-time
Region: US
Department: Research & Development
About This Role
New drugs are discovered through creative design and pioneering medicinal chemistry. In this role, you will leverage your modeling skills and knowledge of computational chemistry to support the design and prioritization of new small molecules aimed to treat neurological and rare diseases. You will be expected to work in a team environment and to effectively communicate with co-workers from a variety of disciplines and scientific backgrounds.
What You’ll Do
Work within a project team as the lead computational chemistry to help with iterative improvement of compound potency and selectivity with desirable physicochemical properties for oral administration for CNS/peripheral targets.
Learn and apply property-based drug design tactics as applied to neuroscience small molecule drug discovery.
Utilize structure and ligand-based drug design with cutting edge software.
Perform virtual screening of internal and commercial compound libraries (including ultra large virtual libraries) against targets.
Perform analysis of high throughput screening results, data mining of internal and external databases to identify new hits.
Perform SAR data analysis to help medicinal chemists in lead optimization.
Perform binding energy calculations including Free Energy simulations of receptor-ligand complexes.
Who You Are
The successful candidate will be a creative and highly motivated scientist with demonstrated expertise in the field of computational chemistry and cheminformatics. You will be expected to stay current with the chemical literature and apply the latest advances in computational methods to address drug discovery project challenges. As a key contributor to small molecule discovery projects, thinking independently to solve complex problems is an important aspect of this position.
Required Skills
Ph.D. in a computational science field (e.g. cheminformatics, computational chemistry).
0-2 years of postdoctoral experience.
Track record of publications, and/or scientific presentations.
Should be able to work in a multidisciplinary team.
Excellent oral and written communication skills.
Preferred Skills
Experience using molecular modeling packages to support structure-based drug design projects for lead generation and lead optimization.
Experience supporting medicinal chemistry optimization campaigns in understanding SAR and building hypotheses.
Excellent knowledge in at least one programming or scripting language (Python preferred)
Knowledge in building predictive models using statistical and machine learning methods supported by a deep understanding of molecular representations.
Experience in the creation of data workflows as well as data analysis and interpretation
Why Biogen?
We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.
At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.
All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.
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Email Alert for Scientist, Computational Chemistry/Cheminformatics jobs in Cambridge, MA, United States
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