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Cerevel Therapeutics
Boston, MA, United States
Role Summary: This is an exciting role for an experienced lab bioanalytical scientist to be part of the growing DMPK (Bioanalytical, BA) group here at Cerevel. He/she will be contributing towards in vitro / in vivo and biomarker quantitation studies along the drug discovery path using cell-culture, quantitative bioanalysis, lab automation and rela
Job Source: Cerevel TherapeuticsCerevel Therapeutics
Boston, MA, United States
Role Summary: Department of Drug Metabolism and Pharmacokinetic group at Cerevel is seeking a passionate Associate Scientist to join the Investigative Biotransformation and Unbiased pharmacometabolomics group to support the early discovery portfolios of a premier Neuroscience company Cerevel Therapeutics. This position will ensure to provide the r
Job Source: Cerevel TherapeuticsBristol Myers Squibb
Cambridge
**Working with Us** Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that tra
Job Source: Bristol Myers SquibbAtavistik Bio
Cambridge, MA, United States
Company Summary: Atavistik Bio is focused on unlocking hidden functional pockets to discover transformative allosteric precision therapeutics to address serious unmet patient needs. By integrating our propriety screening technology using the body's natural regulators, with our powerful AI-enabled drug discovery platform, we are able to efficiently
Job Source: Atavistik BioAtavistik Bio, Inc.
Cambridge, MA, United States
Company Summary: Atavistik Bio is a privately-held biopharmaceutical company that is pioneering a systematic, scalable approach to identify and harness highly conserved protein-metabolite interactions to revolutionize small molecule drug discovery. Combined, our Atavistik Metabolite-Protein Screening (AMPS) platform and structure-based drug design
Job Source: Atavistik Bio, Inc.Cerevel Therapeutics, LLC
Boston, MA, United States
**Principal Scientist, Biotransformation** Posted: 08/03/2021 Boston, MA **Company Overview** Cerevel Therapeutics is dedicated to unraveling the mysteries of the brain to treat neuroscience diseases. We are tackling neuroscience diseases with a differentiated approach that combines expertise in neurocircuitry with a focus on receptor selectivity.
Job Source: Cerevel Therapeutics, LLCBicycle Therapeutics
Cambridge, MA, United States
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geo
Job Source: Bicycle TherapeuticsOdyssey Therapeutics
Boston, MA, United States
About Us Odyssey Therapeutics is propelling drug development beyond what is now possible to deliver medicines that address critical needs of patients with inflammatory diseases and cancer. We achieve unprecedented speed and efficiency by bringing together a target-centric approach, a toolbox of cutting-edge technologies, and a team of accomplished
Job Source: Odyssey TherapeuticsBoston, MA, United States
Job Description We are currently seeking a highly skilled and motivated individual to provide quantitative modeling guidance and perform hands-on Quantitative systems pharmacology (QSP), PKPD and PBPK modeling for research and development programs at Vertex.In this role the qualified candidate will act as a lead preclinical PKPD modeling expert in interdisciplinary teams to support the drug discovery and development process by applying his/her knowledge and technical expertise to quantitatively characterize the pharmacokinetics, pharmacodynamics, and biomarker (PK/PD/Biomarker) properties of drug candidates. Quantitative understanding of the target and degree of modulation required for disease progression modification is necessary for setting human target exposure and desirable PK profiles. A thorough understanding of the biology, mechanism of action, efficacy biomarker and DMPK properties is essential for this individual to build mechanism-based mathematical models and update such models to incorporate new information throughout the lifespan of the projects. In addition, his/her core responsibilities also include PBPK modeling to integrate preclinical in vitro data for absorption and drug-drug interaction predictions. Prior experience with regulatory submissions of such PBPK DDI modeling work is highly desirable. The candidate may serve as a project team representative for discovery and development projects. Key Duties And Responsibilities Develop/code and validate mathematical PK/PD/Biomarker/Efficacy models to elucidate the quantitative PK/PD relationships in pre-clinical species.
Perform advanced troubleshooting for the related mathematical models independently.
Work with Clinical Pharmacology to assess the clinical potential for drug-to-drug interactions using physiology-based PK (PBPK) modeling tools (e.g., SimCYP).
Apply expertise in drug metabolism and pharmacokinetics (DMPK) principles and translational QP and PKPD methodologies as studies move from preclinical to clinical phases.
Draft PBPK reports in support of regulatory submissions.
Demonstrate an astute understanding of the PKPD and QSP field and the relevant literature.
Utilize pre-clinical data for human efficacious dose prediction.
Prepare peer-directed presentations for the internal scientific communit
Education And Experience Ph.D. (or equivalent degree) in Chemical Engineering, Pharmaceutical Sciences, or related discipline with 4+ years of related experience
PKPD modeling software, such as MATLAB, Phoenix, ADAPT and NONMEM
PBPK modeling software, such as Gastroplus, SimCYP
Basic programming language: R, Python, etc.
Prior DMPK team lead experience
Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected].
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Email Alert for DMPK Principal Scientist, M&S Modeler jobs in Boston, MA, United States
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