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Takeda Pharmaceuticals
Boston, MA, United States
By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my
Job Source: Takeda PharmaceuticalsTakeda Pharmaceutical
Boston
By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best
Job Source: Takeda PharmaceuticalTakeda
Boston, MA, United States
By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’sPrivacy Noticeand Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge. Job
Job Source: TakedaHarbour Antibodies BV
Boston, MA, United States
About > Employment > Sr Principal Scientist Job Title: Principal Scientist/Senior Principal Scientist Field: Immunology and Inflammation Company: Harbour BioMed Location: Newton/Boston, MA, USA Company Description Harbour BioMed is a biopharmaceutical company headquartered in Shanghai with business operations and research centers in Boston
Job Source: Harbour Antibodies BVTakeda
Boston, MA, United States
At Takeda, we strive to provide transformational opportunities for every member of our team, and we empower our people to take charge of their futures. In an environment that fosters lifelong learning and a growth mindset, you’ll have the support you need to thrive — at work and beyond. Job ID R0121830 Date posted 04/26/2024 Location Multi
Job Source: TakedaPristine Infotech, Inc.
Boston, MA, United States
Role: Principal AI Scientist Experience: 3 to 5 years Qualification: PhD in AI, Comp Science, Math or Stats from exceptional institutions PRISTINE IS LOOKING FOR – Principal AI Scientist Can you architect real-time optimized recommendation engines leveraging cognitive, prescriptive, explainable AI? Can you develop self-learning models? Can you
Job Source: Pristine Infotech, Inc.Pearl Health
Boston, MA, United States
Who We Are. . . Pearl Health is restoring the independence and joy of practicing medicine for doctors in the United States. Our healthcare system has burdened our doctors with too much process, while removing them from what they do best: caring for those we love most. We are a team of physicians and public health experts (Stanford, Dartmouth, Harv
Job Source: Pearl HealthImprivata
Waltham, MA, United States
Description Come join a winning team! Here at Imprivata, you’ll see a dedicated group of professionals who care about improving healthcare. Our team thrives on collaboration and sharing ideas, whether in a cross-functional meeting or at one of our virtual team-building events. While we're diverse in our backgrounds and skills, we have much in com
Job Source: ImprivataBoston, MA, United States
**Principal Scientist, Biotransformation**
Posted: 08/03/2021
Boston, MA
**Company Overview**
Cerevel Therapeutics is dedicated to unraveling the mysteries of the brain to treat neuroscience diseases. We are tackling neuroscience diseases with a differentiated approach that combines expertise in neurocircuitry with a focus on receptor selectivity. Our portfolio of pre-commercial neuroscience assets targets a broad range of central nervous system (CNS) disorders, including schizophrenia, epilepsy, Parkinsons disease and substance use disorder.
Headquartered in the Greater Boston area, we are bold thinkers, deep experts, resilient pathfinders, and transparent partners who push the boundaries of scientific understanding to unlock breakthrough CNS therapies that have real impact on peoples lives.
Cerevel aspires to develop and nurture a culture characterized by trust, respect, courage, curiosity, and compassion, with a relentless focus on mission and results. Our patient-centricity guides our purpose, how we treat each other and what we work on every day. The successful candidate will bring their own unique thinking and approach to Cerevel while sharing our core values and convictions.
**Role Summary**
**We are seeking an exceptional individual for a Principal Scientist position within the DMPK group. The successful candidate will have a strong experimental background with an established track record of hands on in vitro/in vivo ADME assay support and technical problem solving. A true experimentalist, the successful candidate ideally has experience supporting and influencing projects with in vitro/in vivo metabolic profiling and identification studies in drug development and/or discovery. Experience in discovery bioanalysis for in vivo PK studies is also helpful. At the senior level, this person will be troubleshooting as well as analytical method problem solving (HRMS/LC- MS/MS) across the discovery & development projects.**
****Key Responsibilities****
* **Design and delivery of fit-for-purpose in vitro/ in vivo metabolic profiling and identification experiments to support discovery or development projects**
* **Independently able to develop, implement and/or troubleshoot analytical methods for analysis of drug metabolites, conduct metabolic profiling and collect appropriate instrumentation data for the determination of metabolite structures and associated pathways**
* **Experience in isolation of metabolites from different matrices and structural elucidation**
* **Be able to troubleshoot, problem solve and define best practice for in vitro ADME experiments**
* **Work closely within DMPK, Cross functional groups and subject matter experts to ensure that in vitro/in vivo DMPK technologies and science are relevant for project teams and portfolio deliverables**
* **Contribute to the scientific in vitro strategy to enhance the value of in vitro DMPK science to support a diversified Cerevel portfolio**
* **Report and communicate scientific ideas and results to senior leaders as needed**
* **Present and publish findings to project teams/Cerevel/external scientific community**
* **Ensure data integrity and data accessibility through the Cerevel R&D data domains**
* **Ensure compliance with Cerevel Values and Policies**
****Required Qualifications****
* **Strong understanding of drug metabolism and ADME principles including enzyme kinetics, analytical method development, metabolite profiling and structural elucidation**
* **In depth experience with in vitro ADME assays, HRMS, bioanalysis and LC-MS/MS**
* **In depth knowledge of laboratory equipment and troubleshooting instrumentation issues, high resolution mass spectrometry with particular focus on MS and MS/MS data collection and basic interpretation**
* **Working knowledge with radiolabeled compounds and samples is preferred**
* **Experience working with project teams to guide them through ADME problem solving using in vitro data would be preferred**
* **Experience in writing and reviewing in vitro reports for regulatory filing is highly desired**
****Desired Qualifications****
* **5+ years of industrial experience in DMPK departments in a drug discovery setting**
* **Previous experience with HRMS for metabolite profiling and identification, automated workflows and LC-MS/MS analysis**
* **Experience in bioanalysis, automation and liquid handling systems would be a plus**
****Education****
* **MS or PhD in organic chemistry, analytical chemistry, Drug Metabolism and Pharmacokinetics or related science such as Pharmacology, Biology, Biochemistry**
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Email Alert for Principal Scientist, Biotransformation jobs in Boston, MA, United States
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