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Vertex Pharmaceuticals
Boston, MA, United States
Job Description We are currently seeking a highly skilled and motivated individual to provide quantitative modeling guidance and perform hands-on Quantitative systems pharmacology (QSP), PKPD and PBPK modeling for research and development programs at Vertex.In this role the qualified candidate will act as a lead preclinical PKPD modeling expert in
Job Source: Vertex PharmaceuticalsBristol Myers Squibb
Cambridge
**Working with Us** Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that tra
Job Source: Bristol Myers SquibbCerevel Therapeutics, LLC
Boston, MA, United States
**Principal Scientist, Biotransformation** Posted: 08/03/2021 Boston, MA **Company Overview** Cerevel Therapeutics is dedicated to unraveling the mysteries of the brain to treat neuroscience diseases. We are tackling neuroscience diseases with a differentiated approach that combines expertise in neurocircuitry with a focus on receptor selectivity.
Job Source: Cerevel Therapeutics, LLCAtavistik Bio
Cambridge, MA, United States
Company Summary: Atavistik Bio is focused on unlocking hidden functional pockets to discover transformative allosteric precision therapeutics to address serious unmet patient needs. By integrating our propriety screening technology using the body's natural regulators, with our powerful AI-enabled drug discovery platform, we are able to efficiently
Job Source: Atavistik BioAtavistik Bio, Inc.
Cambridge, MA, United States
Company Summary: Atavistik Bio is a privately-held biopharmaceutical company that is pioneering a systematic, scalable approach to identify and harness highly conserved protein-metabolite interactions to revolutionize small molecule drug discovery. Combined, our Atavistik Metabolite-Protein Screening (AMPS) platform and structure-based drug design
Job Source: Atavistik Bio, Inc.Harbour Antibodies BV
Boston, MA, United States
About > Employment > Sr Principal Scientist Job Title: Principal Scientist/Senior Principal Scientist Field: Immunology and Inflammation Company: Harbour BioMed Location: Newton/Boston, MA, USA Company Description Harbour BioMed is a biopharmaceutical company headquartered in Shanghai with business operations and research centers in Boston
Job Source: Harbour Antibodies BVPristine Infotech, Inc.
Boston, MA, United States
Role: Principal AI Scientist Experience: 3 to 5 years Qualification: PhD in AI, Comp Science, Math or Stats from exceptional institutions PRISTINE IS LOOKING FOR – Principal AI Scientist Can you architect real-time optimized recommendation engines leveraging cognitive, prescriptive, explainable AI? Can you develop self-learning models? Can you
Job Source: Pristine Infotech, Inc.Bicycle Therapeutics
Cambridge, MA, United States
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geo
Job Source: Bicycle TherapeuticsBoston, MA, United States
Role Summary:
This is an exciting role for an experienced lab bioanalytical scientist to be part of the growing DMPK (Bioanalytical, BA) group here at Cerevel. He/she will be contributing towards in vitro / in vivo and biomarker quantitation studies along the drug discovery path using cell-culture, quantitative bioanalysis, lab automation and related lab skills, especially for early-stage programs in the company portfolio. This is a matrixed position that will involve frequent interactions with discovery research team members from cross-functional groups such as Chemistry, in vivo Biology, Translational Medicine and Toxicology. This role additionally offers a great learning/growth opportunity to improve the understanding of different aspects of the DMPK function in drug discovery.
Key Responsibilities
Independent scientific contributor in collaboration with other research functional groups supporting preclinical biomarkers and bioanalytical assays
Preparing and analyzing BA study samples and generating high quality bioanalytical/LC-MS data to support non-GLP studies, as part of a matrix environment. Also being involved in study design, in concert with all stakeholders
Basic cell-culturing familiarity to contribute with cell-line maintenance for ADME assays
Actively participate in laboratory automation of bioanalytical assays
Learn and perform new and existing quantitative biomarker assays - small molecule and/or proteins using LBA or LC/MS approaches
Mentor, transfer assay development and instrumentation knowledge to other scientists
Address complex issues related to bioanalysis working in collaboration with internal/external scientific groups for innovative solutions
Documenting the experimental design, results and conclusions in Electronic Lab Notebook (ELN) and uploading summary reports to Cerevel data repository including working via our new cloud-based LIMS platform
Learn multidisciplinary activities as a representative in early research project teams to foster collaborations and lead activities in future
Authoring and presenting scientific findings at internal and/or external scientific meetings
Required Qualifications
Ph.D with 5 -8 yrs work experience, may include post doctoral experience; or BS/MS (in Chemistry/Analytical Chemistry, Biochemistry or related discipline) with 12+ years work experience, preferably, in the industry
Extensive hands-on experience with LC-MS bioanalysis of small molecules will be required. Exposure to LBA approach for quantitation will be essential. Other modality experience will be an advantage
Good understanding of bioanalytical (BA) and related processes used in the laboratory as well as a broader understanding of the drug discovery process and DMPK function will be necessary
Related lab skills for this position include cell culture experience, exposure and experience in lab automation, innovative solutions to create high throughput assays, experience with LIMS systems for documentation and data archival
Experience monitoring and interacting with external CROs to outsource activities
Strong learning capabilities, high scientific integrity, good interpersonal and communication skills
Ability to work in a fast-paced environment and in a team setting in a self-motivated way
Education
Ph.D or MS or BS (Cell/Molecular Biology, Biochemistry, Analytical Chemistry or related discipline)
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Email Alert for Principal Scientist, DMPK jobs in Boston, MA, United States
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