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Odyssey Therapeutics, Inc.
Boston, MA, United States
Odyssey Therapeutics is propelling drug development beyond what is now possible to deliver medicines that address critical needs of patients with inflammatory diseases and cancer. We achieve unprecedented speed and efficiency by bringing together a target-centric approach, a toolbox of cutting-edge technologies, and a team of accomplished, world-cl
Job Source: Odyssey Therapeutics, Inc.Delix Therapeutics
Bedford, MA, United States
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Job Source: Delix TherapeuticsBicycle Therapeutics
Cambridge, MA, United States
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geo
Job Source: Bicycle TherapeuticsBristol-Myers Squibb
Cambridge, MA, United States
Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transf
Job Source: Bristol-Myers SquibbAtavistik Bio, Inc.
Cambridge, MA, United States
Company Summary: Atavistik Bio is a privately-held biopharmaceutical company that is pioneering a systematic, scalable approach to identify and harness highly conserved protein-metabolite interactions to revolutionize small molecule drug discovery. Combined, our Atavistik Metabolite-Protein Screening (AMPS) platform and structure-based drug design
Job Source: Atavistik Bio, Inc.Atavistik Bio
Cambridge, MA, United States
Company Summary: Atavistik Bio is focused on unlocking hidden functional pockets to discover transformative allosteric precision therapeutics to address serious unmet patient needs. By integrating our propriety screening technology using the body's natural regulators, with our powerful AI-enabled drug discovery platform, we are able to efficiently
Job Source: Atavistik BioPrime Medicine
Cambridge, MA, United States
The Senior Director of Pharmacology and DMPK reporting to the Head of Nonclinical Development will provide scientific, strategic, and hands-on leadership and execution of our R&D-wide strategy for Research. She/he will lead consulting and externally partnered resources, in Discovery and In Vivo Pharmacology, ADME, DMPK, PK/PD Modeling, Colony & CRO
Job Source: Prime MedicineFogPharma
Cambridge, MA, United States
Why Join Us? FogPharma is a biopharmaceutical company pioneering the discovery and development of Helicon™ therapeutics, which are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, FogPharma is poised to revolutionize the medical possibilities for patients by
Job Source: FogPharmaBoston, MA, United States
About Us
Odyssey Therapeutics is propelling drug development beyond what is now possible to deliver medicines that address critical needs of patients with inflammatory diseases and cancer. We achieve unprecedented speed and efficiency by bringing together a target-centric approach, a toolbox of cutting-edge technologies, and a team of accomplished, world-class drug hunters. By reimagining the drug development process, we are creating a deep and broad drug pipeline that holds the potential to transform human health.
Position Details
Job Title: Sr/Director DMPK
Location: Boston, MA
Employment Type: Full-Time
Department: Non-Clinical Development
The Opportunity
The Sr/Director drug metabolism-pharmacokinetics (DMPK) will oversee the company’s DMPK function and will play a key role in the discovery and advancement of Odyssey’s small molecule therapeutic portfolio. This role will serve as the function head, applying subject matter expertise in absorption, distribution, metabolism, and excretion (ADME), pharmacokinetics (PK), and pharmacodynamics to drive the strategy and execution of our pre-clinical programs. The candidate will be expected to collaborate cross functionally to develop and implement studies vital to address key program DMPK issues and successfully advance pre-clinical compounds into development.
Key Responsibilities
In partnership with senior discovery and development leadership, set the DMPK strategy and plans for Odyssey’s small molecule research and development portfolio
Establish and oversee activities at CROs, including in vitro ADME, PK, bioanalysis and PK/PD modeling
Build DMPK capabilities, externally and internally
Be the functional area representative for DMPK on project teams, collaborating closely with medicinal chemistry and biology/pharmacology
Design, analyze and interpret preclinical DMPK studies in support of program goals and objectives
Use a broad array of DMPK data to enable integrated analyses of biopharmaceutics, drug metabolism, PK/PD, human PK/dose projections and risk of drug-drug interactions
Author and review study reports and relevant sections of regulatory documents
About You
An advanced degree, such as MS with 15+ years of experience or PhD. with 10+ years of experience, with a focus in pharmacokinetics, pharmacology or related discipline
Proactive at solving complex problems within a collaborative, multidisciplinary team environment
Technical depth and a broad understanding of small molecule DMPK, with experience from early discovery through to IND
Extensive experience optimizing and characterizing the ADME properties of small molecule drug candidates, supported by a strong publication record in DMPK sciences. Expertise in the interplay between DMPK parameters, physicochemical and molecular properties
Proficient in the management of activities at CROs and comfortable working in virtual outsourced model.
Expertise in PK/PD modeling from discovery through early development; proficient with Phoenix WinNonlin or similar
Experience leading DMPK on projects particularly in discovery and early development
Operational experience and familiarity with the drug discovery and development process, including external regulatory requirements
Outstanding oral and written communication, and organizational skills; comfortable navigating complexity and ambiguity in a fast-paced environment interacting with consultants, external vendors, and internal cross-functional, global project teams
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Email Alert for Sr / Director DMPK jobs in Boston, MA, United States
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