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Prime Medicine
Cambridge, MA, United States
The Senior Director of Pharmacology and DMPK reporting to the Head of Nonclinical Development will provide scientific, strategic, and hands-on leadership and execution of our R&D-wide strategy for Research. She/he will lead consulting and externally partnered resources, in Discovery and In Vivo Pharmacology, ADME, DMPK, PK/PD Modeling, Colony & CRO
Job Source: Prime MedicineBristol-Myers Squibb
Cambridge, MA, United States
Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transf
Job Source: Bristol-Myers SquibbOdyssey Therapeutics
Boston, MA, United States
About Us Odyssey Therapeutics is propelling drug development beyond what is now possible to deliver medicines that address critical needs of patients with inflammatory diseases and cancer. We achieve unprecedented speed and efficiency by bringing together a target-centric approach, a toolbox of cutting-edge technologies, and a team of accomplished
Job Source: Odyssey TherapeuticsAtavistik Bio, Inc.
Cambridge, MA, United States
Company Summary: Atavistik Bio is a privately-held biopharmaceutical company that is pioneering a systematic, scalable approach to identify and harness highly conserved protein-metabolite interactions to revolutionize small molecule drug discovery. Combined, our Atavistik Metabolite-Protein Screening (AMPS) platform and structure-based drug design
Job Source: Atavistik Bio, Inc.Atavistik Bio
Cambridge, MA, United States
Company Summary: Atavistik Bio is focused on unlocking hidden functional pockets to discover transformative allosteric precision therapeutics to address serious unmet patient needs. By integrating our propriety screening technology using the body's natural regulators, with our powerful AI-enabled drug discovery platform, we are able to efficiently
Job Source: Atavistik BioOdyssey Therapeutics, Inc.
Boston, MA, United States
Odyssey Therapeutics is propelling drug development beyond what is now possible to deliver medicines that address critical needs of patients with inflammatory diseases and cancer. We achieve unprecedented speed and efficiency by bringing together a target-centric approach, a toolbox of cutting-edge technologies, and a team of accomplished, world-cl
Job Source: Odyssey Therapeutics, Inc.FogPharma
Cambridge, MA, United States
Why Join Us? FogPharma is a biopharmaceutical company pioneering the discovery and development of Helicon™ therapeutics, which are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, FogPharma is poised to revolutionize the medical possibilities for patients by
Job Source: FogPharmaStratacuity: Proven Scientific Placement
Watertown, MA, United States
Location: Watertown MA (Onsite) Science/Focus: Immunological Diseases Job Overview: This job requires partnering with various project teams, setting DMPK strategy, and driving execution of projects in the pharmaceutical industry, utilizing strong expertise in PK/ADME strategies, PK and PK/PD modeling, and excelling in a collaborative and fast-pa
Job Source: Stratacuity: Proven Scientific PlacementCambridge, MA, United States
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating BT8009, a Bicycle Toxin Conjugate (BTC ) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA ) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle Radio Conjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.
Culture is key and all Bicycle employees actively embrace and role model our company values:
Weare Adventurous .We believe it’sthewaytodeliverextraordinaryresultsforourpatients.
Weare DedicatedtoourMission .Youcan’tchangetheworldifyoudon’thavedetermination.
Weare OneTeam .Weonlysucceedwhenweworktogether.
Job Description
The Senior Director of Drug Metabolism and Pharmacokinetics (DMPK) reports to the Vice President of Quantitative Pharmacology group. In partnership with drug discovery medicinal chemists, biologists, pharmacologists and toxicologists, you will be responsible for leading a small team of DMPK scientists supporting multiple projects from target identification through to candidate selection and ultimately regulatory submission.
Provide DMPK scientific leadership across all stages of the portfolio.
Oversee the quality and performance of all DMPK activities including interactions with external CRO’s and internal project stakeholders.
Work collaboratively with other core disciplines to support compound progression based on optimizing DMPK properties.
Integrate data from multiple sources to inform on the understanding of bicyclic peptide distribution, metabolism and excretion.
Work closely with in-vivo pharmacology to design experiments to understand preclinical pharmacokinetic/pharmacodynamic (pk/pd) relationships.
Work closely with discovery team and regulatory team to author and review DMPK related IND documents
Managing DMPK budgets for CRO’s and monitoring CROs to ensure delivery of quality data on time.
Support leadership of the Quantitative Pharmacology group and junior staff development
Qualifications
Essential:
PhD in relevant scientific discipline such as drug metabolism, pharmacology, pharmaceutical sciences.
Significant experience working on DMPK drug discovery and/or development projects with a track record of successful delivery.
In depth understanding of DMPK science with additional knowledge of related disciplines.
Demonstrated expertise in DMPK problem solving across drug discovery.
Ability to adapt your working style to suit different cultures and partner expectations in both remote and office-based environment.
Excellent organisation and communication skills, both written and oral, with the ability to influence.
Desirable:
Previous experience working on peptides-macrocycles would be an advantage.
Nice-to-have: experience on radio-pharm projects
Additional Information
Flexible working environment
Competitive reward including annual company bonus
Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
Health and Dependent Care Flexible Spending Accounts
401(k) plan with a 4% Company match and immediate vesting
Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
Employee assistance program
Employee recognition schemes
10 Company holidays
Competitive Family Leave Policy
Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
All your information will be kept confidential according to EEO guidelines.
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
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Email Alert for Senior Director, DMPK jobs in Cambridge, MA, United States
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