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Atavistik Bio, Inc.
Cambridge, MA, United States
Company Summary: Atavistik Bio is a privately-held biopharmaceutical company that is pioneering a systematic, scalable approach to identify and harness highly conserved protein-metabolite interactions to revolutionize small molecule drug discovery. Combined, our Atavistik Metabolite-Protein Screening (AMPS) platform and structure-based drug design
Job Source: Atavistik Bio, Inc.Stratacuity: Proven Scientific Placement
Watertown, MA, United States
Location: Watertown MA (Onsite) Science/Focus: Immunological Diseases Job Overview: This job requires partnering with various project teams, setting DMPK strategy, and driving execution of projects in the pharmaceutical industry, utilizing strong expertise in PK/ADME strategies, PK and PK/PD modeling, and excelling in a collaborative and fast-pa
Job Source: Stratacuity: Proven Scientific PlacementOdyssey Therapeutics
Boston, MA, United States
About Us Odyssey Therapeutics is propelling drug development beyond what is now possible to deliver medicines that address critical needs of patients with inflammatory diseases and cancer. We achieve unprecedented speed and efficiency by bringing together a target-centric approach, a toolbox of cutting-edge technologies, and a team of accomplished
Job Source: Odyssey TherapeuticsBristol-Myers Squibb
Cambridge, MA, United States
Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transf
Job Source: Bristol-Myers SquibbBicycle Therapeutics
Cambridge, MA, United States
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geo
Job Source: Bicycle TherapeuticsBristol-Myers Squibb
Cambridge, MA, United States
**Working with Us** Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that tra
Job Source: Bristol-Myers SquibbOdyssey Therapeutics, Inc.
Boston, MA, United States
Odyssey Therapeutics is propelling drug development beyond what is now possible to deliver medicines that address critical needs of patients with inflammatory diseases and cancer. We achieve unprecedented speed and efficiency by bringing together a target-centric approach, a toolbox of cutting-edge technologies, and a team of accomplished, world-cl
Job Source: Odyssey Therapeutics, Inc.Bristol Myers Squibb
Cambridge
**Working with Us** Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that tra
Job Source: Bristol Myers SquibbCambridge, MA, United States
Company Summary:
Atavistik Bio is focused on unlocking hidden functional pockets to discover transformative allosteric precision therapeutics to address serious unmet patient needs. By integrating our propriety screening technology using the body's natural regulators, with our powerful AI-enabled drug discovery platform, we are able to efficiently identify novel, biologically relevant allosteric sites for protein or RNA targets, and rapidly advance structural insights into small molecule therapeutics design. Atavistik is advancing multiple high value oncology programs and anticipates initiating clinical development in early 2025. Atavistik is based in Cambridge, MA and backed by leading biotech venture capital firms The Column Group, Nextech and Lux Capital.
Position Summary:
We are seeking a passionate and creative Associate Director, DMPK, to join our development group and work with an enthusiastic team of highly skilled scientists in a dynamic, high-growth company. Reporting to the VP, Chemical Sciences, this individual will be responsible for the design, execution, and interpretation of non-clinical DMPK, and toxicology studies. This work supports the progression of therapies from late discovery through first in human and proof of concept clinical studies. This is a great opportunity to build an efficient DMPK function while being part of an exciting early-stage company.
Key Responsibilities:
Representative DMPK leader as a member of program, research, preclinical and IND-enabling teams.
Function as a key member of Atavistik Bio's scientific leadership team, providing scientific expertise, strategic planning, and goal-oriented execution.
Effectively communicate scientific planning, progress, and results to executive leadership, R&D teams, and external audiences. Additionally, build and develop appropriate relationships with key opinion leaders and SAB members.
Propose ADME/PK, biodistribution, and PK-PD approaches at team discussions of high impact on project progression.
Identify and manage consultants and vendors to support ADME, PK and PK/PD studies.
Contribute to candidate selection, development strategy, and coordinate IND-enabling study reports.
Partner with the discovery group to optimize preclinical models and inform on first in human clinical dosing strategies.
Review preclinical study reports, in conjunction with Pharmacokinetics/DMPK and prepare regulatory submission documentation.
Author DMPK, nonclinical toxicology, and biomarker sections of regulatory documents.
Collaborate cross functionally with all relevant areas to support strategic objectives
Communicate status updates and program issues to appropriate team members.
Required Qualifications:
Ph.D., Pharm. D., or equivalent training in pharmacokinetics, pharmaceutical sciences, or related disciplines.
Minimum 7 years of experience in bio/pharmaceutical industry, combined with drug development
Excellent communication and collaborative skills to work on project teams with chemists, biologists, and platform scientists.
Highly organized, self-motivated with a desire to succeed in a fast-paced organization
Experience with regulatory submissions for small molecules with a focus on preclinical and early clinical development strategy and execution.
Experience in nonclinical toxicology is a plus.
Solid understanding of drug metabolism, bioanalysis, pharmacokinetics, preclinical pharmacology, PK/PD modeling and clinical study designs.
Expertise managing CROs, GLP, and other regulated activities.
Ability to operate objectively and independently as a leader and as a member of a team.
Must be able to work on multiple projects simultaneously.
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Email Alert for Associate Director, DMPK jobs in Cambridge, MA, United States
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