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General Proximity
San Francisco, CA, United States
tl;dr General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking first-rate chemical biol
Job Source: General ProximityFirefly Bio
San Francisco, CA, United States
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Job Source: Firefly BioApertor Pharmaceuticals
Alameda, CA, United States
Apertor Pharmaceuticals Inc. was founded in November 2020 and will bring new therapies to patients by engineering molecular glues using synthetic biology. We apply a world-class synthetic biology platform using non-model organisms, a deep knowledge of natural products relevant to human health, and a computational pipeline enabled by structure-guide
Job Source: Apertor PharmaceuticalsThe University of Texas MD Anderson Cancer Center
San Francisco, CA, United States
Job Title: Scientist/Sr. Scientist, Structural Biology Job Number: 77949 Location: San Francisco, CA,US Job Description tl;dr General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therap
Job Source: The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer Center
San Francisco, CA, United States
Job Title: Principal Scientist/Director, Chemical Biology Job Number: 78085 Location: San Francisco, CA,US Job Description tl;dr General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome the
Job Source: The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer Center
San Francisco, CA, United States
Job Title: Scientist/Sr. Scientist, Lead Discovery Job Number: 77952 Location: San Francisco, CA,US Job Description tl;dr General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeuti
Job Source: The University of Texas MD Anderson Cancer CenterMission Bio
South San Francisco, CA, United States
About the job Are you ready to join Mission Bio, a Series D company based in South San Francisco, California!! Our mission is to help researchers and clinicians unlock single-cell biology to enable the discovery, development, and delivery of precision medicine. We are a dynamic and diverse team. We live by the culture of “One Cell, One Team, One Vi
Job Source: Mission BioEnvivo
San Francisco, CA, United States
At Envivo Bio, we are looking for people from a wide variety of backgrounds and experiences who can challenge assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national or
Job Source: EnvivoSan Francisco, CA, United States
tl;dr
Weatherwax Biotechnologies is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine yields molecules that co-opt existing cellular machinery to overcome exigent therapeutic challenges which have remained unapproachable to other modalities for decades.
We are seeking first-rate chemical biologists to help us pioneer this uncharted frontier of drug discovery.
Our Story
A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or “undruggable” targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA approved drugs is inhibition[ 1 ], but there are many other possible perturbation types whose potential remains unrealized.
Weatherwax Biotechnologies is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).
Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our approach will be no different.
The Position
We are seeking an experienced chemical biologist to be a founding member of our Platform/Drug Discovery Team. In this position you will work in close conjunction with our Biology Team in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.
Your responsibilities will include: supervising synthetic efforts with our CROs, designing and performing both low and high-throughput screening assays, managing compound libraries, performing mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.
About You
High Agency . Initiative, independence, and self-accountability are some of our most valued traits.
Enthusiastic . We love people who are excited about what they are doing, and are generally attempting to build a high-energy team.
Intensity and Grit . Early-stage startups are hard. Drug discovery doubly so. We are looking for candidates who have a demonstrated ability to stick with hard problems for the long haul, with a team that has your back along the way.
Prosocial . We are here to create life-saving medicines for the patients who need it most. You should be too.
Qualifications & Nice-To-Haves
PhD in Chemical Biology, Medicinal Chemistry, Pharmacology, or related field.
Industry experience is desirable, but the ability to work hard and learn fast is more important to us.
Deep understanding of small-molecule drug discovery and its relationship to human disease.
Strong experience with:
Hit finding and hit-to-lead studies
HTS and phenotypic assay development and screening
Small molecule binding affinity assays
PPI techniques e.g. BRET, APEX/BioID, AlphaScreen
Proficiency in:
Platform development
Compound management
Disease model development
Biochemical assay development
Nice to have:
Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc
Familiarity or experience with PROTAC technology
Biophysical screening techniques such as SPR or fluorescence anisotropy
DEL experience
Experience with med-chem optimizations: SAR, PK/PD, etc
Computational drug discovery experience
Prior experience on teams that have successfully advanced research to the clinic
Experience managing others
Benefits
Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
Top tier medical, dental, and vision coverage + One Medical membership.
401(k) retirement plans.
Education and health/fitness incentive programs.
Reading budget! We will buy you books ????
Located in the MBC BioLabs Dogpatch site; an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.
About Us
Work Hard/Play Hard . We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we’re at work we’re there to get things done and when we’re off we’re really off.
Strong Communication . We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.
Writing First . We have a “writing-first” culture. We believe that clarity of writing reflects clarity of thinking, and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.
Growth . As an early-stage startup we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive-feedback loops so you can grow in the direction of your choosing.
Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you ????
More info at jobs.weatherwax.bio
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Email Alert for Scientist/Sr. Scientist | Chemical Biology Weatherwax Bio jobs in San Francisco, CA, United States
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