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General Proximity
San Francisco, CA, United States
tl;dr General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking first-rate chemical biol
Job Source: General ProximityMBC BioLabs
San Francisco, CA, United States
tl;dr Weatherwax Biotechnologies is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine yields molecules that co-opt existing cellular machinery to overcome exigent therapeutic challenges which have remained unapproachable to other modalities for decades. We are seeking first-rate
Job Source: MBC BioLabsThe University of Texas MD Anderson Cancer Center
San Francisco, CA, United States
Job Title: Principal Scientist/Director, Chemical Biology Job Number: 78085 Location: San Francisco, CA,US Job Description tl;dr General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome the
Job Source: The University of Texas MD Anderson Cancer CenterFirefly Bio
San Francisco, CA, United States
About Firefly Bio: Firefly specializes in Degrader Antibody Conjugates (DACs) which combine the unique strengths of ADCs with selective protein degraders. Our mission is to unlock the full potential of bioconjugates and develop medicines with long-lasting benefits for patients. We are establishing an expert team to build state-of-the-art platform
Job Source: Firefly BioThe University of Texas MD Anderson Cancer Center
San Francisco, CA, United States
Job Title: Scientist/Sr. Scientist, Structural Biology Job Number: 77949 Location: San Francisco, CA,US Job Description tl;dr General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therap
Job Source: The University of Texas MD Anderson Cancer CenterThe Chan Zuckerberg Biohub, Inc.
San Francisco, CA, United States
The Opportunity Reporting to the Director of Computational Biology and Data Science , the Research Scientist will have primary responsibility for developing multimodal data fusion strategies and building innovative AI/ML models to enable CZ Biohub research in San Francisco. You will Develop multimodal data fusion strategies; building, deploying and
Job Source: The Chan Zuckerberg Biohub, Inc.BigHat Biosciences
San Mateo, CA, United States
Senior Data Scientist, Computational Biology Department: DS/ML (Data Science/Machine Learning) Employment Type: Full Time Location: San Mateo, CA Description The Role: BigHat Biosciences is seeking an exceptional Senior Data Scientist to join our growing team. This position will accelerate BigHat's data science capabilities focused on adva
Job Source: BigHat BiosciencesThe Cell Company (CellCo)
San Francisco, CA, United States
At CellCo, we are at the forefront of merging synthetic biology with AI to decode the complexity of mammalian systems and generate breakthrough therapeutics. We leverage cutting-edge technology to program novel molecular circuits, including cell and cell-free approaches, while incorporating biomimicry—learning from nature’s own strategies. We are c
Job Source: The Cell Company (CellCo)Alameda, CA, United States
Apertor Pharmaceuticals Inc. was founded in November 2020 and will bring new therapies to patients by engineering molecular glues using synthetic biology. We apply a world-class synthetic biology platform using non-model organisms, a deep knowledge of natural products relevant to human health, and a computational pipeline enabled by structure-guided design. The result is a first-in-class approach to solving important pharmacological problems and delivering new, high-value treatment options for patients. Our principal offices are in Alameda, CA.
Apertor Pharmaceuticals is seeking a (Senior) Scientist - Chemical Biology to design and execute target identification and mechanism of action studies to discover and develop novel small molecules for therapeutic applications in oncology. This pivotal role requires expertise in chemical biology techniques, a deep understanding of cancer biology, and the ability to work collaboratively within a multidisciplinary research team. A passion for drug discovery and development for cancer patients is essential.
This role is required to be onsite full time at our office in Alameda, CA.
Responsibilities:
Develop and execute affinity-based assays to probe protein-protein and protein-small molecule interactions in the cellular environment.
Apply affinity-based assays to characterize small molecules.
Develop and implement genetic/genomic methods for on/off target studies, both in vitro and in vivo.
Work collaboratively with chemists and biologists to provide the project team with scientific expertise and critical path assessments.
Carefully document experimental details, data, and findings.
Maintain the organization and safety of chemistry and biology research areas.
Maintain lab instruments
Preferred Education and Experience:
Candidates should hold a degree in Biochemistry, Pharmacology, Chemical Biology, Organic Chemistry, or a related discipline.
Senior Scientist: Ph.D. + postdoc and/or industry experience (5+ years)
Scientist: Ph.D. + postdoc and/or industry experience (0+ years)
Required Qualifications:
Deep understanding of small molecule drug discovery and development, particularly in relation to cancer.
Exceptional ability to discern and elucidate connections between diverse scientific findings across disciplines. Demonstrated ability to take ownership of research projects, from conception through to execution and reporting.
Extensive experience with mammalian cell culture. Essential skills include cell culturing, transient expression, and stable cell line generation.
Solid knowledge and bench skills in affinity-based assays from cell lysate, including (Co)IP-Western and biosensor-based quantitative (Co)IP, as well as IP-MS (DDA, DIA, and TMT).
Hands-on experience with molecular biology experiments, including plasmid design, construction, and sequence validation.
Knowledge of organic chemistry.
Preferred Qualifications
Experience with gene-editing using CRISPR in mammalian cells.
Experience with translational medicine.
Experience with cancer bioinformatics.
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Email Alert for Senior Scientist/Scientist - Chemical Biology jobs in Alameda, CA, United States
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