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Xilio Therapeutics
Waltham, MA, United States
Principal Scientist – Biotherapeutics Engineering Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using i
Job Source: Xilio TherapeuticsBristol Myers Squibb
Cambridge
**Working with Us** Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that tra
Job Source: Bristol Myers SquibbNovartis Farmacéutica
Cambridge, MA, United States
Associate Director / Director Biotherapeutics (Dual Posting) Job ID 388653BR USA About the Role Posting Title: Assoc Director/Director Biotherapeutics (Dual Posting) Onsite #LI-Onsite About the role: We are seeking a PhD and/or MD professional who is a scientific leader in the field of biologics drug discovery especially antibody drug conju
Job Source: Novartis FarmacéuticaBristol Myers Squibb
Cambridge
**Working with Us** Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that tra
Job Source: Bristol Myers SquibbElektrofi
Boston, MA, United States
ABOUT ELEKTROFI Elektrofi is a biopharmaceutical formulation technology company that is revolutionizing the delivery of biologic therapies by giving patients the ability to control how they want to receive and benefit from life-changing medicines. Our breakthrough ultra-high concentration microparticle technology platform resolves the limitations
Job Source: ElektrofiHarbour Antibodies BV
Boston, MA, United States
Job Title: Scientist/Senior Scientist Field: Immunology and Inflammation Company: Harbour BioMed Location: Newton/Boston, MA, USA Company Description Harbour BioMed is a biopharmaceutical company headquartered in Shanghai with business operations and research centers in Boston and Netherlands. Harbour BioMed leverages its proprietary transgenic
Job Source: Harbour Antibodies BVBristol Myers Squibb
Cambridge
**Working with Us** Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that tra
Job Source: Bristol Myers SquibbHillstar Bio
Boston, MA, United States
About the Company Hillstar Bio, is a precision immunology company that recently completed a sizable Series A financing with a syndicate of blue-chip investors. Our passionate team of drug developers is based in Boston's Seaport neighborhood. Hillstar is advancing a portfolio of programs against autoimmune diseases with unmet or underserved medica
Job Source: Hillstar BioBoston, MA, United States
DESCRIPTION Incendia Therapeutics is seeking an exceptional and highly motivated Senior Scientist to join the Biotherapeutics Drug Discovery group. The successful applicant will support therapeutic antibody discovery and optimization campaigns – including leading reagent generation strategies, developing antibody campaign workplans and screening funnels, overseeing the execution of the campaigns through CRO partners, and optimizing lead antibodies for development candidate selection. RESPONSIBILITIES Reporting to the Director, Biotherapeutics the Senior Scientist will be part of the Biotherapeutics Drug Discovery team. Here's What You'll Do: Collaborate with project teams to identify and generate key reagents needed for target validation and antibody campaigns including proteins, antibodies, and engineered cell lines
Interface with CRO antibody partners to execute antibody discovery, humanization, and optimization campaigns
Oversee CROs to produce recombinant proteins and antibodies for in vitro screening and scale-up for in vivo studies, manage in-house inventory, help build LIMS and lab as company grows
Collaborate with project teams to support Development Candidate nomination, including developing screening funnels and assays to support hit-to-lead identification
Develop and implement analytical methods to support Biophysical assessment, including affinity measurements, and Developability characterization
Help build structural modeling capabilities for rational design optimization
REQUIREMENTS & QUALIFICATIONS Qualifications include: Degree in Biochemistry, Molecular/Cellular Biology, or a related field + indicated years of industry experience: Ph.D. + 1-3 yrs – or
M.S. + 8-10 yrs – or
B.S. +10-12 yrs
Experience with multiple antibody discovery platforms including in vivo immunization and in vitro display approaches
Knowledge of antibody engineering: humanization, affinity maturation, sequence analysis & optimization
Experience developing & implementing high-throughput screening assays including, ELISA, cell-based binding FACS, reporter cell lines, HTRF, AlphaLISA
Direct experience with development of therapeutic antibodies
CRO management experience
Experience within silico tools for developability screening, antibody engineering, LIMS
Excellent verbal and written communication and interpersonal skills for participating across functional groups and externally
Demonstrated commitment to quality, attention to detail, and team player mentality
Demonstrated ability to think critically and creatively as part of a fast-paced research team
Preferred Qualifications: Knowledge of protein structure and modeling to enable rational design & lead optimization
Knowledge of techniques and instrumentation related to protein characterization and analytics (SPR/BLI binding, LC/MS, peptide mapping, PTM characterization, HPLC, DSC, DLS, etc.)
Understanding of cell line development and CMC activities
Benefits Competitive salary and benefits package
Opportunity for professional development and career advancement
A supportive and innovative work environment
Access to cutting-edge technology and research tool
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Email Alert for SENIOR SCIENTIST – BIOTHERAPEUTICS jobs in Boston, MA, United States
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