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Incendia Therapeutics Inc
Boston, MA, United States
DESCRIPTION Incendia Therapeutics is seeking an exceptional and highly motivated Senior Scientist to join the Biotherapeutics Drug Discovery group. The successful applicant will support therapeutic antibody discovery and optimization campaigns – including leading reagent generation strategies, developing antibody campaign workpl
Job Source: Incendia Therapeutics IncNewton Colmore
Boston, MA, United States
Description Newton Colmore is partnered with a biotech company in Boston, MA, and we are searching for a principal-level scientist with expertise in protein engineering. As a Principal Scientist within this organisation, you will be utilising your expertise to design and execute protein engineering strategies, design and develop new assays for ki
Job Source: Newton ColmoreHarbour Antibodies BV
Boston, MA, United States
About > Employment > Sr Principal Scientist Job Title: Principal Scientist/Senior Principal Scientist Field: Immunology and Inflammation Company: Harbour BioMed Location: Newton/Boston, MA, USA Company Description Harbour BioMed is a biopharmaceutical company headquartered in Shanghai with business operations and research centers in Boston
Job Source: Harbour Antibodies BVCytiva
Marlborough, MA, United States
Be part of something altogether life-changing! Working at Cytiva means being at the forefront of providing new solutions to transform human health. Our incredible customers undertake life-saving activities ranging from fundamental biological research to developing innovative vaccines, new medicines, and cell and gene therapies. At Cytiva you will
Job Source: CytivaAlkermes
Waltham, MA, United States
Job Description Position Summary: The Principal Scientist position within Analytical Development provides technical leadership for small molecule analytical methodologies and grows as a subject matter expert both within and outside the department as part of a growing, dynamic Pharmaceutical Development organization. They will work within the Anal
Job Source: AlkermesPristine Infotech, Inc.
Boston, MA, United States
Role: Principal AI Scientist Experience: 3 to 5 years Qualification: PhD in AI, Comp Science, Math or Stats from exceptional institutions PRISTINE IS LOOKING FOR – Principal AI Scientist Can you architect real-time optimized recommendation engines leveraging cognitive, prescriptive, explainable AI? Can you develop self-learning models? Can you
Job Source: Pristine Infotech, Inc.Capital One
Cambridge, MA, United States
Center 2 (19050), United States of America, McLean, Virginia Principal Data Scientist, Consumer Identity Machine Learning Data is at the center of everything we do. As a startup, we disrupted the credit card industry by individually personalizing every credit card offer using statistical modeling and the relational database, cutting edge technolog
Job Source: Capital OneExponent Inc.
Natick, MA, United States
About Exponent: Exponent is the only premium engineering and scientific consulting firm with the depth and breadth of expertise to solve our clients most profoundly unique, unprecedented, and urgent challenges. We are committed to engaging multidisciplinary teams of science, engineering, and regulatory experts to empower our clients with solutio
Job Source: Exponent Inc.Waltham, MA, United States
Principal Scientist – Biotherapeutics Engineering
Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using its proprietary platform to advance a pipeline of novel, tumor-activated clinical and preclinical I-O molecules that are designed to optimize their therapeutic index by localizing anti-tumor activity within the tumor microenvironment, including tumor-activated cytokines and antibodies (including bispecifics) and immune cell engagers (including tumor-activated cell engagers and tumor-activated effector-enhanced cell engagers). Learn more by visiting www.xiliotx.com and follow us on LinkedIn ( Xilio Therapeutics, Inc .)
SUMMARY:
We are seeking a highly skilled and experienced Principal Scientist in Biotherapeutics Engineering to design and optimize biologics-based drugs, incorporating structural biology expertise as well as innovative computational methods. The successful candidate will have a strong background in structural biology, protein engineering and antibody discovery workflows. A solid background in applying machine learning techniques and molecular modeling to improve the biophysical and biological properties of biotherapeutics is highly desired. The candidate is expected to have expertise in leading cross-functional teams, generating key data, and driving projects from in silico concepts to in vivo proof of concept (PoC).
Job Responsibilities:
Apply state-of-the-art in silico biotherapeutic engineering tools, CCG-MOE or Schrodinger-Maestro and/or others, to design and optimize biologics-based drugs.
Apply cutting-edge generative AI, machine learning and molecular modeling techniques to help identify novel binders and/or enhance the properties of biologics-based drugs, including target engagement, developability, immunogenicity, and protease specificity.
Perform biochemical and biophysical characterization of designed/engineered proteins to examine protein function as well as identify and develop structure-function relationships.
Lead or co-lead research project team, accountable for defining project strategy, ensuring effective execution of activities to meet project goals and timelines.
Represent Protein Engineering at project team meetings.
Support writing and reporting of key experiments in IND filings.
Capture detailed experimental information in electronic lab notebook (ELN) entries.
Skills, Qualifications, and Requirements:
PhD in Structural Biology, Chemical and Biomolecular Engineering or a related field and a minimum of 7 years of relevant post-graduate experience in industry or academic setting.
Strong expertise in biotherapeutics engineering, with a focus on computational methods for drug design and optimization is required.
Expertise in protein design and bioinformatics, including molecular modeling (homology modeling and molecular dynamics simulations) using in silico tools such as MOE, Maestro, NAMD, Schroedinger or VMD, etc. is required.
Strong analytical and problem-solving skills for computational analysis of protein, DNA, and mRNA sequences is required.
Demonstrated experience in applying machine learning techniques to improve the properties of biologics-based drugs is desired.
Knowledge of various generative AI/machine learning algorithms (RFDiffusion, Alphafold, Chroma, etc.) and experience in data mining using APIs is desired.
Experience in cloud computing and/or in writing code (SQL, R, python) for data wrangling and analytics is desired
Familiarity with electronic lab notebooks (such as Benchling) for data mining and analysis is desired.
Proven track record of leading cross-functional teams and successfully delivering projects from in silico concepts to in vivo proof of concept is preferred.
Excellent leadership and communication skills to effectively lead cross-functional teams and collaborate with stakeholders is required.
Diversity, Equity and Inclusion
At Xilio Therapeutics, we foster a culture of equity, diversity and inclusion. We consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law. We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability who requires accommodation with the hiring process or to perform any essential functions of the position for which you are applying, please reach out to [email protected] .
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Email Alert for Principal Scientist, Biotherapeutics Engineering jobs in Waltham, MA, United States
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