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Kestrel Therapeutics
Boston, MA, United States
Associate Director/Director, Medicinal Chemistry At Kestrel our aspiration is to invent brilliant technologies and develop novel small molecule agents for cancer targets of exceptional scientific and clinical import, beginning with mutant RAS. Our reliance is on the rigorous application of innovative science in the service of the discovery of new
Job Source: Kestrel TherapeuticsMeet
Boston, MA, United States
Primary Responsibilities This pivotal role involves leading the discovery and refinement of drug lead molecules. Key responsibilities include: Strategic Planning : Develop and implement a strategic plan for identifying targeting peptides and linker-payload combinations that align with the company's R&D goals. Team Leadership : Lead and manage a cro
Job Source: MeetJnana Therapeutics, Inc.
Boston, MA, United States
About Us Jnana Therapeutics is a clinical-stage biotechnology company leveraging its next-generation RAPID chemoproteomics platform to discover medicines for highly validated, challenging-to-drug targets to treat diseases with high unmet needs. Jnana is focused on developing first- and best-in-class therapies to treat a wide range of diseases, in
Job Source: Jnana Therapeutics, Inc.1910genetics
Boston, MA, United States
Computation is revolutionizing drug discovery. Advances in bigchemical data, massive computing power, artificial intelligence, andmolecular dynamics simulation are changing the way we develop newdrugs. At 1910 Genetics, we put computation at the heart of drugdiscovery, blending expertise in computational chemistry, structuralbiology, pharmacology,
Job Source: 1910geneticsNovartis Group Companies
Cambridge, MA, United States
390639BR Senior Principal Scientist, Computational Medicinal Chemistry USA About the role Internal Role Title: AD and Senior Principal Scientist, Data Science Location: Cambridge, MA About this role: Join our vibrant and innovative Computer-Aided Drug Discovery (CADD) team in Cambridge, where we bring together diverse talents to redefine th
Job Source: Novartis Group CompaniesNovartis Farmacéutica
Cambridge, MA, United States
Senior Principal Scientist, Computational Medicinal Chemistry Job ID 390639BR Jan 23, 2024 USA About the Role Internal Role Title: AD and Senior Principal Scientist, Data Science Location: Cambridge, MA About this role: Join our vibrant and innovative Computer-Aided Drug Discovery (CADD) team in Cambridge, where we bring together diverse t
Job Source: Novartis Farmacéutica1910genetics
Boston, MA, United States
1910 Genetics is the only company that has built a synergistic, dual-purpose small and large molecule platform that integrates artificial intelligence (AI), computation, and biological automation to design drug-like molecules better, faster, and cheaper than traditional approaches.Based in the Seaport District of Boston, 1910 Genetics is a Series A
Job Source: 1910geneticsNovartis
Cambridge, MA, United States
Senior Principal Scientist, Computational Medicinal Chemistry Job ID 390639BR Jan 23, 2024 USA About the Role Internal Role Title: AD and Senior Principal Scientist, Data Science Location: Cambridge, MA About this role: Join our vibrant and innovative Computer-Aided Drug Discovery (CADD) team in Cambridge, where we bring together diverse t
Job Source: NovartisBoston, MA, United States
Director/Senior Director of Medicinal Chemistry Computation is revolutionizing drug discovery. Advances in bigchemical data, massive computing power, artificial intelligence, andmolecular dynamics simulation are changing the way we develop newdrugs. At 1910 Genetics, we put computation at the heart of drugdiscovery, blending expertise in computational chemistry, structuralbiology, pharmacology, genetics, data science, and softwareengineering to develop drugs for previously undruggable targets.
We are seeking an experienced and highly motivated Medicinal Chemistry Director/Senior Director.
The ideal candidate has the following qualifications: A track record of effective scientific decision making, people management and organizational effectiveness to advance small molecule drug discovery campaigns from hit discovery to development candidate
A broad knowledge and personal experience with diverse target classes
Demonstrated the ability to collaborate, build trust and influence across internal multi-disciplinary teams
Demonstrated the ability to thrive in an entrepreneurial, fast-paced, and innovative environment effectively coordinating multiple distributed resources
Excellent written and oral communication skills
Excelled in a multidisciplinary environment both as a leader and member across multiple project teams
Responsibilities Design, implement and execute synthetic and medicinal chemistry strategies
Design novel ligands based on internal, or literature published data that would contribute to new target initiatives
Identify synthetic pain points and advise on optimal solutions
Apply emerging synthetic chemistry and purification methodology and technology in the design and synthesis of novel ligands
Confirm viability of design proposals from AI research and Computational Chemistry groups or offer alternative routes
Establish strategies to leverage external resource and capabilities
Effectively plan resource allocation to achieve team goals
Provide strategic, scientific, and managerial leadership in an outsourced Medicinal Chemistry environment
Effectively manage synthetic CROs to achieve project objectives and be responsible for the quality of compounds delivered
Collaborate and contribute to multidisciplinary drug discovery project teams
Effectively articulate medicinal chemistry goals and strategies and build consensus across functions
Influence the cross-functional scientific growth
Provide timely and well-organized reports to project teams
Collaborate effectively with the leadership team and other departments and functions
Provide expertise and leadership in the management, storage, and quality control of compounds in the internal collection, define best practices and quality standards
Evaluate and make recommendations for chemistry-centric needs such as equipment, reagents, hardware, and software
Be knowledgeable and effectively utilize software such as Torx, LiveDesign, Spotfire, StarDrop, DataWarrior etc. that are used for review, analysis, and prediction of data to enhance decision making in design and prioritization
Establish the intellectual property strategy for each program and work with patent counsels and agents
Lead the preparation of patent applications and peer reviewed scientific publications
Qualifications Doctoral degree (Ph.D.) or equivalent in synthetic organic chemistry or medicinal chemistry
10+ years of experience in the biotech and/or pharmaceutical industry, with a strong track record of scientific innovation and success in delivering clinical candidates
Demonstrated leadership of project teams in a cross-functional environment
In-depth knowledge of the drug R&D process with expertise in the application of ADME/PK and pharmacology data to optimize drug candidates
A leader with effective organizational, interpersonal, communication and managerial skills who can motivate and inspire others
Demonstrated technical proficiency, scientific creativity, independent thought, and ability to effectively collaborate with others
Extremely generous equity package coupled with competitive salary
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Email Alert for Director/Senior Director of Medicinal Chemistry jobs in Boston, MA, United States
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