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Third Harmonic Bio
Cambridge, MA, United States
About Third Harmonic Bio Third Harmonic Bio is a biopharmaceutical company with a singular purpose: To create a breakthrough treatment for people living with severe allergy and inflammation - debilitating conditions that can take a significant toll on overall health and well-being. We are developing a highly selective oral wild-type KIT inhibitor
Job Source: Third Harmonic BioNovo Nordisk
Lexington, MA, United States
About the Department Our Boston Research & Development hub, anchored in the greater Boston area, brings together the best minds in life science innovation. The teams located in facilities in Lexington, Watertown and Cambridge reflect the full R&D continuum, from early research through late-stage clinical development. Here, we are building for the
Job Source: Novo Nordisk1910genetics
Boston, MA, United States
Director/Senior Director of Medicinal Chemistry Computation is revolutionizing drug discovery. Advances in bigchemical data, massive computing power, artificial intelligence, andmolecular dynamics simulation are changing the way we develop newdrugs. At 1910 Genetics, we put computation at the heart of drugdiscovery, blending expertise in c
Job Source: 1910geneticsMeet
Boston, MA, United States
Primary Responsibilities This pivotal role involves leading the discovery and refinement of drug lead molecules. Key responsibilities include: Strategic Planning : Develop and implement a strategic plan for identifying targeting peptides and linker-payload combinations that align with the company's R&D goals. Team Leadership : Lead and manage a cro
Job Source: Meet1910genetics
Boston, MA, United States
Computation is revolutionizing drug discovery. Advances in bigchemical data, massive computing power, artificial intelligence, andmolecular dynamics simulation are changing the way we develop newdrugs. At 1910 Genetics, we put computation at the heart of drugdiscovery, blending expertise in computational chemistry, structuralbiology, pharmacology,
Job Source: 1910geneticsVertex Pharmaceuticals, Inc
Boston, MA, United States
Job Description As a key team leader in the Manufacturing Sciences & Technology function, the Associate Director, Analytical Sciences & Technology, Small Molecules- Drug Substance is accountable for all activities and resources associated with the commercialization and management of analytical activities for commercial programs for Vertex's small
Job Source: Vertex Pharmaceuticals, Inc1910genetics
Boston, MA, United States
1910 Genetics is the only company that has built a synergistic, dual-purpose small and large molecule platform that integrates artificial intelligence (AI), computation, and biological automation to design drug-like molecules better, faster, and cheaper than traditional approaches.Based in the Seaport District of Boston, 1910 Genetics is a Series A
Job Source: 1910geneticsMSD Malaysia
Cambridge, MA, United States
Director, Computational Chemistry page is loaded Director, Computational Chemistry Apply remote type Not Applicable locations USA - Massachusetts - Boston (MA Parcel B Laboratory) time type Full time posted on Posted 3 Days Ago job requisition id R293540 Job Description We are seeking a creative and pas
Job Source: MSD MalaysiaBoston, MA, United States
Associate Director/Director, Medicinal Chemistry
At Kestrel our aspiration is to invent brilliant technologies and develop novel small molecule agents for cancer targets of exceptional scientific and clinical import, beginning with mutant RAS. Our reliance is on the rigorous application of innovative science in the service of the discovery of new medicines for people with cancer. Our priority is patients, always.
Kestrel is an oncology biotech start-up in its early stages of growth, having been in operation since January of 2022. We have excellent funding and, having moved into our new laboratory space in early 2023, are in the process of expanding our team.
We are seeking an outstanding individual to lead our medicinal chemistry activities. The candidate should be a self-motivated and influential leader with a strong record of accomplishment in medicinal chemistry and project leadership. Proven ability to effectively design small molecules and manage a team of contract chemists is required as is the ability to excel in a collaborative multidisciplinary environment.
The successful candidate will assume the role of Associate Director/Director of Medicinal Chemistry and will report directly to the Vice President of Medicinal Chemistry.
Key Responsibilities :
· Lead integrated medicinal chemistry projects from hit generation through the lead optimization process.
· Manage project specific resources including external chemistry personnel.
· Must show keen attention to timelines to rapidly advance projects and achieve program goals.
· Plan, execute, interpret, and optimize structure activity relationship campaigns.
· Plan complex chemical syntheses as needed to deliver high quality molecules for biological screening.
· Develop new IP and lead the preparation of project specific patent documents as appropriate.
· Build and maintain productive relationships with internal and external collaborators in biology, pharmacology, computational chemistry, DMPK, toxicology, and early development.
· Ability to communicate project updates clearly and effectively to key stakeholders.
Professional Experience & Qualifications :
· Level will be dependent on experience.
· Ph. D. in Organic Chemistry or related field with 7+ years of experience working in a pharmaceutical / biotechnology setting as a medicinal chemist.
· Demonstrated leadership in medicinal chemistry and drug discovery as evidenced by a strong record of scientific accomplishment and cross-functional collaboration.
· Outstanding synthetic chemistry background and a demonstrated track record of aptitude and problem solving in medicinal chemistry.
· Expertise in using structure-based drug design principles and computational chemistry tools for medicinal chemistry design.
· Demonstrated experience delivering compounds from hit identification to development candidate selection.
· Experience in working with CRO partners and proven ability to work efficiently in a hybrid research model.
· Excellent written and oral communication skills.
Kestrel Therapeutics offers a generous benefits package including medical, dental, vision, and disability insurance, as well as paid time off and a 401k plan.
Kestrel Therapeutics is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, ethnicity, color, national origin, religion, age, marital status, veteran status, disability, genetic information, sexual orientation, gender identity or any other basis protected by federal, state, or local law.
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Email Alert for Associate Director/Director Medicinal Chemistry jobs in Boston, MA, United States
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