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Associate Director - Translational Biomarker (Immunology)

Waltham, MA, United States

Associate Director (Principal Investigator) – Translational Biomarker (Immunology)

We are seeking an experienced translational scientist to lead the design and execution of biomarker strategies supporting our early and late-stage research programs. The candidate will develop translational biomarker approaches that measure target engagement, pharmacodynamics, and disease pathology. As a strategic leader within a multidisciplinary team, the candidate will ensure that biomarker strategies align with the most current understanding of inflammatory disease biology and enable early clinical proof-of-concept. This role involves a hands-on approach in the pre-clinical validation of these approaches using disease biospecimens. This is a unique opportunity to work at the interface of discovery and development while championing biomarker initiatives that directly impact novel clinical study design.

Responsibilities :

Spearhead the creation and execution of translational biomarker strategies to evaluate proof of mechanism, detect early efficacy signals, and facilitate proof-of-concept studies

Work closely with preclinical scientists to design and carry out translational research aimed at validating biomarker approaches

Coordinate with research and clinical teams to integrate biomarker discoveries into early clinical study designs

Supervise the clinical validation of biomarker assays and collaborate with clinical pharmacology to analyze clinical biomarker studies

Actively contribute to the discovery pipeline as a key biology team member

Requirements :

PhD in Immunology with a minimum of 8 years of experience in the pharmaceutical or biotechnology industry

Proven experience in small molecule drug discovery and program leadership

Expertise in identifying and validating pharmacodynamic and disease biomarkers, along with their clinical application

Capability to guide and influence projects from discovery through early clinical development, focusing on identifying indications and formulating biomarker strategies for early proof-of-concept

Exceptional analytical, research, and organizational abilities

Excellent interpersonal, influencing, and collaboration skills

Proficient in prioritizing tasks, highly productive, and adaptable in a dynamic, team-oriented environment

Ability to effectively communicate scientific findings to a wide range of audiences

Additional Notes :

Candidates must have excellent communication and strategic thinking skills, with the ability to act as a clinical biomarker lead and a strategic thought partner

Candidates must be within driving distance to MA or willing to relocate

Ideal candidates should have around 3-4 years of experience at the Principal Scientist level and demonstrate advanced leadership capabilities

The ability to communicate sophisticated biomarker strategies effectively is crucial

Candidates should possess the communication and management skills of a project leader

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