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Birdseye Partners
Waltham, MA, United States
Associate Director (Principal Investigator) – Translational Biomarker (Immunology) We are seeking an experienced translational scientist to lead the design and execution of biomarker strategies supporting our early and late-stage research programs. The candidate will develop translational biomarker approaches that measure target engagement, pharmac
Job Source: Birdseye PartnersBicycle Therapeutics
Cambridge, Massachusetts
Job Description We are looking to recruit a Senior data scientist with a strong software engineering and data analytics skillset as well as an oncology background to join our Translational Sciences team. This person would be responsible for leading the development, customization, and maintenance of a biomarker software solution to support our clin
Job Source: Bicycle TherapeuticsTakeda Pharmaceutical Company Limited
Boston, MA, United States
By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.
Job Source: Takeda Pharmaceutical Company LimitedTakeda
Boston, MA, United States
By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my
Job Source: TakedaAstraZeneca GmbH
Boston, MA, United States
This is what you will do: The Director of Translational Research will be responsible for: Translational activities for rare nephrology focused translational research group within the Translational and biomarker research group at Alexion, AZ rare disease Research Department in New Haven. Setting and overseeing the implementation of translational an
Job Source: AstraZeneca GmbHTakeda
Boston, MA, United States
Associate Director Translational Biomarker Lead Liver disease – MASH fibrosis, ECD GI²-TAU Takeda has been translating science into breakthrough medicines for 240 years. Every step of the way, our teams have worked together to tackle some of the most challenging problems in drug discovery and development. Today, we’re a driving force behind innova
Job Source: TakedaModerna, Inc.
Cambridge, MA, United States
The Role: Moderna is seeking an innovative, highly collaborative, strategic, and effective translational medicine leader to establish the translational medicine function for our exciting and transformational rare disease mRNA therapeutics pipeline. This position is based in the new Translational Medicine function in our growing Therapeutics & Onco
Job Source: Moderna, Inc.Eisai
Cambridge, MA, United States
At Eisai, satisfying unmet medical needs and increasing the benefits healthcare provides to patients, their families, and caregivers is Eisai's human health care (hhc) mission. We're a growing pharmaceutical company that is breaking through in neurology and oncology, with a strong emphasis on research and development. Our history includes the devel
Job Source: EisaiBoston, MA, United States
Role Summary
The Department of Research and Translational Medicine is seeking a Principal Scientist, Translational Biomarkers. This person will have direct experience in biomarker selection and execution strategies in support of clinical development of programs. This is an on-site position based in the Apogee lab in the Seaport district in Boston.
Key Responsibilities
In this highly collaborative role, you will work closely with members in Research and Translational Medicine to define the translational biomarker strategies using flow cytometry, multiplex assays, proteomics, and genomics-based tools for programs in early discovery phase.
You will work closely with preclinical teams on biomarker strategies and readouts for building data packages for discovery and translational research programs.
Lead the selection and management of external CROs (clinical research organizations) for procurement of clinical samples for discovery and translational biomarker efforts using omics, proteomics, and data mining tools.
Establish relationships with CROs to execute the strategy including qualification of novel matrices, transfer in-house assays, monitor assay qualification/validation and biomarker testing from patient samples to ensure high quality biomarker data.
Oversee development and analysis of biomarker data generation using multiple platforms including gene expression, soluble/fluid and flow-cytometry based tools.
Conduct experiments in the lab to assess assay feasibility, design and undertake experiments to troubleshoot assay performance issues.
Contribute to biomarker sections of all regulatory documents, including INDs and other study related documents.
Ideal Candidate
PhD with a minimum of 6 years of pharmaceutical/biotech industry experience.
Extensive experience in clinical biomarker strategy and execution, deep understanding of drug development stages and role for biomarkers.
Experience in I&I indications.
Expertise in overseeing flow cytometry, genomics, and protein (LBA) based assays for biomarker discovery and development.
Highly experienced in leading and collaborating effectively as a member of cross-functional teams, excellent communication skills to drive projects and manage timelines and budget, and present to a variety of stakeholders and tailor message accordingly.
Enjoys fast paced environment, flexible, able to manage multiple and competing priorities under tight timelines.
Successfully exhibit Apogee’s C.O.R.E. values: Caring, Original, Resilient and Egoless
Ability and willingness to travel including a minimum of 6 times per year for All Hands meetings and other workshops.
Ability and willingness to work on-site at the Apogee lab in Boston.
The anticipated salary range for candidates for this role will be $185,000-200,000/year. The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography.
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Email Alert for Principal Scientist, Translational Biomarkers jobs in Boston, MA, United States
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