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Beam Therapeutics
Cambridge, MA, United States
Position Overview: Beam is seeking a principal scientist with expertise in nanoparticle process and formulation development. In this role, the individual will work closely with the Discovery, Technical Development, Manufacturing and Analytical groups to advance our early pipeline into development.The candidate will work on formulation and scale up
Job Source: Beam TherapeuticsBeam Therapeutics
Cambridge, MA, United States
Position Overview We are recruiting a Scientist/Sr. Scientist with experience in phase-appropriate analytical method development, optimization, and qualification of physicochemical assays for lot release, stability, and characterization of cell and gene therapy products to support Beam’s in vivo programs using lipid nanoparticle (LNP) delivery. In
Job Source: Beam TherapeuticsCRISPR Therapeutics
Boston, MA, United States
Company Overview Since its inception over a decade ago,CRISPR Therapeuticshas transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and r
Job Source: CRISPR TherapeuticsCRISPR Therapeutics
Boston
Job Description Job Description Company Overview Since its inception over a decade ago, CRISPR Therapeutics has transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, rege
Job Source: CRISPR TherapeuticsCRISPR Therapeutics
Cambridge, MA, United States
**CRISPR Therapeutics** **Senior Scientist, Non-viral Delivery** **Non-Viral Delivery - Cambridge, MA - Full Time** **Company Overview** CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene
Job Source: CRISPR TherapeuticsGarudatx
Burlington, MA, United States
Garuda Therapeutics, a biotechnology company focused on developing off-the-shelf human hematopoietic stem cell-based cellular therapies, is seeking a highly motivated associate / senior associate to join its growing team. The full-time role will be a key member of the process development team, focusing on scaling up pluripotent stem cell expansion
Job Source: GarudatxGaruda Therapeutics, Inc.
Watertown
Job Description Job Description Garuda Therapeutics, a biotechnology company focused on developing off-the-shelf human hematopoietic stem cell-based cellular therapies, is seeking a highly motivated Scientist to join its growing team. The full-time role will be a key member of the process development team, focusing on scaling up pluripotent stem
Job Source: Garuda Therapeutics, Inc.Amgen Inc. (IR)
Cambridge, MA, United States
Process Development Scientist page is loaded Process Development Scientist Apply remote type Flex Commuter / Hybrid locations US - Massachusetts - Cambridge time type Full time posted on Posted 3 Days Ago job requisition id R-184067 Career Category Scientific Job Description HOW MIGHT YOU DEFY IMAG
Job Source: Amgen Inc. (IR)Cambridge, MA, United States
Position Summary:
Orbital is seeking an exceptional Sr. Scientist/Engineer with deep expertise in nanoparticle process and formulation development. In this role, the individual will work closely with the Delivery, Process Development, and Analytical groups, as well as external CDMOs, to advance our early pipeline into development. The candidate will work on formulation and scale up of lipid nanoparticles (LNPs) and other non-viral delivery matrices targeting different organs and cell types for a variety of therapeutic applications.
Responsibilities:
Lead and support the development and scale-up of lipid nanoparticle production across mixing geometries, scales, components, and payloads.
Design and execute experiments to enable a robust and reproducible formulation process for manufacture of clinical trial materials.
Design and execute experiments both independently and as a team to evaluate and optimize drug product stability.
Collaborate with internal Delivery, Process Development and Analytical groups, as well as external manufacturing CDMOs.
Provide support with tech transfer activities for manufacturing of drug product.
Generate high quality documentation in support of regulatory filings and tech transfer.
Communicate and present rigorous scientific findings both internally and externally.
Qualifications:
M.S. or Ph.D. in Pharmaceutical Sciences, Chemical engineering, Bioengineering or a related field.
6-8+ years of experience including at least 6 years of drug product CMC development is required.
Must have a deep understanding of lipid nanoparticle formulation for RNA therapeutics.
Prior industry experience with nanoparticle formulation and scale-up is required.
Familiarity with ultrafiltration and aseptic unit operations for sterile drug product manufacture.
Experience using statistical computer languages and modeling software (R, Python, SLQ, JMP, etc.) to manipulate data and draw insights from large data sets.
Knowledge of statistical techniques and concepts (regression, properties of distributions, statistical tests and proper usage, etc.) is a plus.
Ability to adapt to increasing scope and complexity of work brought on by growth/change.
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Senior Scientist/Engineer, LNP Process Development jobs in Cambridge, MA, United States
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