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CRISPR Therapeutics
Boston
Job Description Job Description Company Overview Since its inception over a decade ago, CRISPR Therapeutics has transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, rege
Job Source: CRISPR TherapeuticsBeam Therapeutics
Cambridge, MA, United States
Position Overview: Beam is seeking a principal scientist with expertise in nanoparticle process and formulation development. In this role, the individual will work closely with the Discovery, Technical Development, Manufacturing and Analytical groups to advance our early pipeline into development.The candidate will work on formulation and scale up
Job Source: Beam TherapeuticsBeam Therapeutics
Cambridge, MA, United States
Position Overview We are recruiting a Scientist/Sr. Scientist with experience in phase-appropriate analytical method development, optimization, and qualification of physicochemical assays for lot release, stability, and characterization of cell and gene therapy products to support Beam’s in vivo programs using lipid nanoparticle (LNP) delivery. In
Job Source: Beam TherapeuticsTessera Therapeutics
Somerville, MA, United States
Company Summary: Tessera Therapeutics is pioneering Gene Writing- a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent bre
Job Source: Tessera TherapeuticsTessera Therapeutics, Inc.
Somerville, MA, United States
Research Associate I/II, LNP Formulations Somerville, Massachusetts, United States BS with up to 4 years of experience, or MS and up to 2 years of experience. Degree in Chemistry, Chemical Engineering, Biomedical Engineering, Material Science, or closely related field Prior experience in LNP delivery or formulations Strong communication and colla
Job Source: Tessera Therapeutics, Inc.Orbital Therapeutics
Cambridge, MA, United States
Position Summary: Orbital is seeking an exceptional Sr. Scientist/Engineer with deep expertise in nanoparticle process and formulation development. In this role, the individual will work closely with the Delivery, Process Development, and Analytical groups, as well as external CDMOs, to advance our early pipeline into development. The candidate wi
Job Source: Orbital TherapeuticsCRISPR Therapeutics
Cambridge, MA, United States
**CRISPR Therapeutics** **Senior Scientist, Non-viral Delivery** **Non-Viral Delivery - Cambridge, MA - Full Time** **Company Overview** CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene
Job Source: CRISPR TherapeuticsFapon
Lexington, MA, United States
Company Description About Us Welcome to the frontier of groundbreaking biotechnology! Nanosent Therapeutics, the RNA Delivery Venture, an innovative biotechnology startup based in Boston, we are on a mission to redefine the boundaries of scientific discovery in RNA delivery. Now, we are on the lookout for a visionary Scientist to join our dynamic t
Job Source: FaponBoston, MA, United States
Company Overview
Since its inception over a decade ago,CRISPR Therapeuticshas transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts,CRISPR Therapeuticshas established strategic partnerships with leading companies includingBayerand Vertex Pharmaceuticals.CRISPR Therapeutics AGis headquartered inZug, Switzerland, with its wholly-ownedU.S.subsidiary,CRISPR Therapeutics, Inc., and R&D operations based inBoston, MassachusettsandSan Francisco, California, and business offices inLondon, United Kingdom
Position Summary
The candidate will be leading our efforts in the design and execution of novel and existing lipid nanoparticle (LNP) formulations to help advance our non-viral delivery platform and take next-gen editing modalities for bespoke indications from concept to clinical application. We are searching for a driven, enthusiastic, and self-motivated individual who is comfortable multitasking and working independently as well as part of a larger team on various aspects of in-vivo delivery. This individual will join the dynamic, rapidly growing, and highly collaborative CRISPR-X division.
Responsibilities
Design, optimize, and execute LNP formulations for a variety of compositions and payloads with minimal supervision
Determine key formulation parameters to provide reproducible and effective LNPs.
Lead the production and characterization of LNPs for various studies enabling a clinical applications.
Work collaboratively with scientists across the organization to advance company goals and enhance the understanding of LNP function.
Be highly organized and meticulous in documenting results in electronic lab notebooks, and present findings to the broader team.
Effectively multitask and manage multiple projects simultaneously.
Stay up to date on in-vivo delivery literature and industrial practice.
Minimum Qualifications
Ph.D. in Bioengineering, Chemical Engineering, Biochemistry, Organic Chemistry, or related field and Scientist I: 0-2 years of relevant experience
Scientist II: 2-5+ years of relevant experience
Extensive hands-on experience and deep expertise in formulating LNPs for gene editing applications in human health.
Hands on experience with HPLC, DLS, Ribogreen, TEM and other analytical methods.
Pays great attention to details in the quality and reproducibility of the LNPs
Strong communication and troubleshooting skills.
A team player with strong interpersonal skills, and ability to collaborate effectively with others.
Preferred Qualifications
Prior experience in LNP conjugation chemistries for drug delivery
Prior experience in using LNPs in mammalian cell culture and animal models.
Competencies
Collaborative – Openness, One Team
Undaunted – Fearless, Can-do attitude
Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
Entrepreneurial Spirit – Proactive. Ownership mindset.
CRISPR Therapeutics believes in fostering a dynamic workplace that balances remote work flexibility with the benefits of in-person interactions. Our employees work at least three days on-site, creating a collaborative work environment, where we cultivate mentorship opportunities, increase cross-functional communication and offer opportunities for our employees to connect. Certain lab based and manufacturing positions are located fully on-site.
CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.
To view our Privacy Statement, please click the following link: http://www.crisprtx.com/about-us/privacy-policy
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Scientist I/II, LNP jobs in Boston, MA, United States
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