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General Proximity
San Francisco, CA, United States
tl;dr General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate cancer bio
Job Source: General ProximityExelixis
Alameda, CA, United States
SUMMARY/JOB PURPOSE: The Principal Bioinformatics Scientist with an emphasis on cancer biology is a highly motivated interdisciplinary, and data scientist who has significant experience in conducting computational analyses of clinical and multi-omics data sets to identify potential mechanisms of drug action and resistance and relationships betw
Job Source: ExelixisAtomwise
San Francisco, CA, United States
[Full Time] Associate Principal Scientist, Biology at Atomwise (United States) | BEAMSTART Jobs Associate Principal Scientist, Biology Atomwise United States Date Posted 20 Apr, 2023 Work Location San Francisco, United States Salary Offered $164400 — $170000 yearly Job Type Full Time Experience Required 6+ years Remote Work Yes Stock Options
Job Source: AtomwiseCircle Pharma, Inc.
South San Francisco, CA, United States
Let the employer know what pronouns you use so that they can address you correctly. Phone Current company Links LinkedIn URL Twitter URL Other website Additional information U.S. Equal Employment Opportunity information (Completion is voluntary and will not subject you to adverse treatment) Our company values diversity. To ensure that we comp
Job Source: Circle Pharma, Inc.The University of Texas MD Anderson Cancer Center
San Francisco, CA, United States
Job Title: Principal Scientist/Director, Chemical Biology Job Number: 78085 Location: San Francisco, CA,US Job Description tl;dr General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome the
Job Source: The University of Texas MD Anderson Cancer CenterApertor Pharmaceuticals
Alameda, CA, United States
Apertor Pharmaceuticals Inc. was founded in November 2020 and will bring new therapies to patients by engineering molecular glues using synthetic biology. We apply a world-class synthetic biology platform using non-model organisms, a deep knowledge of natural products relevant to human health, and a computational pipeline enabled by structure-guide
Job Source: Apertor PharmaceuticalsUniversity of California - San Francisco
San Francisco, CA, United States
Application Window Open date: April 25, 2024 Next review date: Friday, May 10, 2024 at 11:59pm (Pacific Time) Apply by this date to ensure full consideration by the committee. Final date: Saturday, Oct 25, 2025 at 11:59pm (Pacific Time) Applications will continue to be accepted until this date, but those received after the review date wi
Job Source: University of California - San FranciscoFirefly Bio
San Francisco, CA, United States
About Firefly Bio: Firefly specializes in Degrader Antibody Conjugates (DACs) which combine the unique strengths of ADCs with selective protein degraders. Our mission is to unlock the full potential of bioconjugates and develop medicines with long-lasting benefits for patients. We are establishing an expert team to build state-of-the-art platform
Job Source: Firefly BioSan Francisco, CA, United States
[Full Time] Associate Principal Scientist, Cancer Biology at Atomwise (United States) | BEAMSTART Jobs Associate Principal Scientist, Cancer Biology Atomwise United States
Date Posted
20 Apr, 2023
Work Location
San Francisco, United States
Salary Offered
$164400 — $170000 yearly
Job Type
Full Time
Experience Required
6+ years
Remote Work
Yes
Stock Options
No
Vacancies
1 available
Company Overview Atomwise is revolutionizing how drugs are discovered with AI. The Company invented the use of deep learning for structure-based drug discovery and is developing a pipeline of small-molecule drug candidates advancing into preclinical studies. The AtomNet® technology has been used to unlock more undruggable targets than any other AI drug discovery platform. Atomwise is tackling over 600 unique disease targets across 775 collaborations spanning more than 250 partners around the world. The Atomwise portfolio of joint ventures and partnerships with leading pharmaceutical, agrochemical, and emerging biotechnology companies represents a collective deal value approaching $7 billion.
To date, Atomwise has raised over $174 million from leading venture capital firms to advance its mission to make better medicines, faster.
To support its mission, further its progress in enterprise building and leverage its robust discovery engine, Atomwise is building biology and pharmacology capabilities to fully leverage its small molecule AI expertise to advance molecules for clinical development. You will work closely with Atomwise interdisciplinary teams to provide guidance on pharmacology strategy, clinical indications of interest, and other aspects of drug development.
Role Summary Atomwise is recruiting an experienced cancer biologist to support the internal oncology drug discovery portfolio into early-stage and late-stage development programs with a goal to design and oversee preclinical studies that will allow the robust evaluation of oncology targets and small molecule candidates. You will provide strategic and technical leadership to the teams supporting oncology drug discovery projects from target discovery through IND-enabling studies.
This role requires excellent communication skills, in-depth knowledge of preclinical cancer biology/pharmacology, and ability to design translational studies to support future clinical activities. You will work effectively with an interdisciplinary team of computational and medicinal chemists, biologists, cheminformaticians, software engineers, CROs, and program managers to define, build, and optimize our preclinical oncology programs.
Key Responsibilities Lead and collaborate with project teams to develop in vitro pharmacology strategies and support Atomwise preclinical oncology programs.
Direct the selection, validation, and analysis of quantitative biophysical, biochemical, and cellular assays to evaluate binding and function of Atomwise molecules across diverse target classes and relevant oncology signaling pathways leveraging CRO partners.
Participate in the evaluation and selection of new Atomwise oncology targets/indications and develop pharmacology criteria for continued advancement of lead molecules and development candidates.
Develop pharmacology criteria for the advancement of early discovery oncology programs from hit identification to lead optimization including key milestones/decision points and timelines, identifying risks and mitigation strategies, and study planning and execution.
Required Qualifications Ph.D. in cancer biology, pharmacology, cell biology, related scientific discipline plus 6+ years of relevant industry experience in oncology.
Extensive hands-on experience building quantitative in vitro assays (biochemical and cellular) and expertise with in vivo pharmacology models in an oncology drug discovery setting.
Demonstrated success in the management of CROs, including evaluation/selection, setting up processes, and quality control.
Experience collaborating with medicinal chemists and project teams to build effective critical paths to drive structure-activity relationships (SAR) and selection of high quality chemical series to support oncology programs.
Demonstrated track record of clear communication, working with a multidisciplinary team, mentoring, and developing talent.
Compensation & benefits Competitive salary, commensurate with experience
Stock compensation plan – you’ll be an Atomwise co-owner
Platinum health, dental, and vision benefits
401k with 4% match
Funding for professional development and conference attendance
Flexible work schedule
Generous parental leave
High performance culture
Great colleagues
Atomwise is an equal opportunity employer and strives to foster an inclusive workplace. Our mission is to develop better medicines faster, and we know that we need a diverse team to develop medicines that serve diverse populations. Accordingly, Atomwise does not make any employment decisions (including but not limited to, hiring, compensation, and promotions) on the basis of race, religion, color, national origin, gender, gender identity, sexual orientation, age, veteran status, disability status, or any other characteristics protected by applicable federal, state, and local law.
We strongly encourage people of diverse backgrounds and perspectives to apply.
*Pay range for this role is between $164,400- $170,000*
About Atomwise Artificial intelligence for drug discovery. Company Size: 51 - 250 People Year Founded: Not Specified Country: United States Company Status: Actively Hiring Looking for Partners Looking for Clients Raising Funds Share This Job
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Email Alert for Associate Principal Scientist, Cancer Biology jobs in San Francisco, CA, United States
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