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Adicet Bio, Inc.
Redwood City, CA, United States
JOIN US! Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer. Adicet is advancing a pipeline of "off-the-shelf" gamma delta T cells, engineered with chimeric antigen receptors (CARs) and adaptors (CAds), to enhance selective tumor targeting and facilitate innate a
Job Source: Adicet Bio, Inc.OmniAb, Inc.
Emeryville, CA, United States
About OmniAb OmniAb provides our pharmaceutical industry partners access to the most diverse antibody repertoires and cutting-edge screening technologies to enable discovery of next-generation therapeutics. We leverage our state-of-the-art technologies to facilitate the discovery of best-in-class antibodies. Within OmniAb are also core capabilities
Job Source: OmniAb, Inc.Adicet Bio Inc.
Redwood City, CA, United States
SCIENTIST/SENIOR SCIENTIST, PROTEIN SCIENCES We are seeking an enthusiastic protein scientist with a strong passion for working at the bench, problem solving, and mentoring junior scientists. The candidate will work on a small team that is responsible for recombinant expression, purification, conjugation, and characterization of diverse proteins t
Job Source: Adicet Bio Inc.Rezotx
San Francisco, CA, United States
About Rezo Therapeutics Rezo is a different kind of biopharma company. Our mission is to dramatically increase the success rate of drug development by building a disease-agnostic, fully-integrated, network biology platform that will redefine our understanding of human disease and ability to treat it. Our Founders and members of the Board are a grou
Job Source: RezotxRezo Therapeutics
San Francisco, CA, United States
About Rezo Therapeutics Rezo is a different kind of biopharma company. Our mission is to dramatically increase the success rate of drug development by building a disease-agnostic, fully-integrated, network biology platform that will redefine our understanding of human disease and ability to treat it. Our Founders and members of the Board are a grou
Job Source: Rezo TherapeuticsMerck
South San Francisco
**Job Description** We are seeking an exceptional and experienced scientist to join the Discovery Biologics Protein Sciences department in South San Francisco to lead both functional area scientists and drug discovery programs. The **Director of Protein Sciences** role carries managerial and oversight responsibilities and will be a key interface wi
Job Source: MerckVaxcyte Inc.
San Carlos, CA, United States
Company Profile: Vaxcyte, Inc. (Nasdaq: PCVX) is a vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. The Company is developing broad-spectrum conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases. Vaxcyte’s lead candidate, VAX-24, is a 2
Job Source: Vaxcyte Inc.Coherus BioSciences
Redwood City, CA, United States
Title: Director/Senior Director, Clinical Science Reports To: Vice President, Clinical Development - Oncology Location : Redwood City, California Classification: Exempt Overview: The Director/Senior Director, Clinical Science will drive the design, planning, implementation and execution of clinical development plans and programs in accordanc
Job Source: Coherus BioSciencesSouth San Francisco, CA, United States
At Lyterian Therapeutics, we are committed to developing medicines for patients in need by co-opting physiologically-relevant protein homeostatic mechanisms to regulate genetically-validated targets.
Position Summary:
As Senior Director of Protein Sciences, you will be responsible for leading our team working to produce and structurally characterize proteins, protein complexes, and protein/compound interactions to support drug discovery platform and programs. You will lead and mentor top-tier scientists using structural biology techniques including X-Ray crystallography and cryo-EM to guide structure-based drug design efforts, and proteomics to characterize target proteins, protein complexes, and enable mechanism of action studies. By collaborating closely with chemists, protein biochemists, biophysicists, and cell biologists, you will uncover fundamental biology and mechanisms behind induced protein homeostasis therapeutic strategies and drive drug discovery to harness protein homeostasis for therapeutic benefit.
Impact You'll Make: Develop our structural biology platform and lead projects to study protein interactions and protein complexes using X-Ray crystallography, cryo-EM, and proteomics
Contribute to our structural and biophysical understanding of induced protein degradation and lead our protein design and protein production efforts
Lead and mentor teams that are designing, optimizing, and implementing assays to further structure activity relationships (SAR) studies and push forward the field of targeted protein degradation (TPD)
Engage in and mentor others to effectively utilize structure-based drug design principles
Collaborate with medicinal and computational chemists, biophysicists, molecular biologists, cell and assay development scientists, bioinformaticians, pharmacologists and translational biologists
Join the Scientific Leadership Team and serve as a scientific leader, mentor and subject matter expert (SME) on multiple project teams
Develop and contribute to company's intellectual property (IP) domain by way of patents and/or publications, often as principal author
Stay up-to-date with emerging scientific literature to enable innovative approaches
Collaborate and communicate across a diverse scientific team to successfully progress Lyterian goals
Qualifications: PhD in structural biology, biochemistry, biophysics, or related discipline with >12 years of relevant postdoctoral or industrial experience, including 7+ years in industry as a key contributor or leader of discovery teams
Experience managing top-tier structural biologists, protein biochemists, and proteomics scientists
Familiarity with computational approaches including data management, automated structure determination, and protein modeling and design packages such as MOE, Rosetta, or Schrödinger
Skills in various protein production platforms
Strong experience in protein purification methods, with demonstrated application and creativity in all aspects of construct design, protein production, isolation, and characterization
Knowledge of protein degradation mechanisms and in particular the biochemistry of ubiquitin system proteins is a plus
Familiarity with proteomics and mass spectrometry is a plus
Evidence of scientific excellence and impact as illustrated by scientific publications and presentations
Ability to manage multiple tasks efficiently, communicate clearly, work within departmental groups, and build open and collaborative relationships
Demonstrated ability to mentor others
Initiative and boldness to dive into a fast-paced new startup
$200,000 - $275,000 a year We encourage candidates of all levels to apply as there is often flexibility on job title and responsibilities. Compensation will be based on a variety of factors, including experience, qualifications, internal equity and location. Lyterian offers a competitive employment package that includes an annual bonus, significant equity, and a generous benefits package including comprehensive health, dental, and vision insurance for our employees and their families, plus gym membership and a 401K match. At Lyterian, we believe that a diverse, open, and inclusive environment and culture is key to our success. We will not be influenced in recruiting, hiring, promoting or any other employment practices by race, color, citizenship status, national origin, ancestry, sex, sexual orientation, gender identity/expression, age, religion, physical or mental disability, medical or genetic condition, marital status, veteran status, or any other characteristics protected under applicable federal, state and local laws. Lyterian will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable laws.
Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.
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Email Alert for Senior Director of Protein Sciences jobs in South San Francisco, CA, United States
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