Scientist, Translational Immunology_

Cambridge

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Job Description

AbbVie’s Immunology R&D organization is expanding its early discovery team at the Immune Profiling Center in Cambridge, MA. We are seeking a highly motivated Scientist with a passion for learning and excellent attention to detail to join the Translational and Transformational Immunology Discovery team. This scientist will specifically support target identification and validation efforts supporting a multi-omics center and collaborating with different teams across R&D and other departments at AbbVie. Our team is seeking a candidate with existing academic or industry experience in molecular biology, preferably NGS technologies, and who is willing to learn and develop new techniques and learn deep analysis using different approaches. Candidates will be expected to have experience with nuclei isolations and scATACseq, as well as routine lab techniques such as DNA/RNA extraction, nucleic acid QC, and PBMC isolation and handing.

Key Responsibilities:

+ Isolate high-quality nuclei from PBMCs and/or tissues for downstream preparation of scATACseq libraries.

+ Execute high-throughput NGS library preparations by working effectively on a team and leveraging the use of automated liquid handlers (e.g. Biomek i7).

+ Operate Illumina sequencers and other lab instrumentation for quality control of NGS Libraries (e.g., Tapestation).

+ Accurately document project and sample information, protocols, and experimental details through the Electronic Lab Notebook (ELN)

+ Conduct experiments, troubleshoot, and optimize protocols independently and in collaboration with colleagues to deliver high-quality data in a timely fashion.

+ Interpret findings and communicate effectively to present scientific data, concepts, and recommendations to various internal audiences. May attend or present at external conferences.

+ Interface with computational biologists and data scientists to generate and interpret scATACseq datasets.

+ Work in AbbVie’s matrixed environment and support activities for different groups across the organization, which may include alignment meetings.

Qualifications

Qualifications:

+ BS or equivalent education with typically 5-9 years of experience or MS or equivalent education with typically 2-7 years of experience.

+ Strong background in basic molecular biology and/or genomics with proficiency in molecular biology lab techniques such as DNA/RNA extraction and nucleic acid QC, as well as familiarity with PBMC isolation and handling

Preferred Qualifications:

+ Experience with nuclei isolation from PBMCs and/or tissues is strongly preferred.

+ Familiarity with 10X Genomics platforms, particularly scATACseq and/or Multiome, is preferred.

+ Familiarity with automated liquid handlers such as Biomek i7 or Tecan Fluent is a plus but not required.

+ Background in R is a plus but not required.

+ Background in immunology is a plus but not required.

Key AbbVie Competencies:

+ Builds strong relationships with peers and cross functionality with partners outside of the team to enable high performance.

+ Learns fast, grasps the “essence”, and can change course quickly where indicated.

+ Raises the bar and is never satisfied with the status quo.

+ Creates a learning environment, open to suggestions and experimentation for improvement.

+ Embraces the ideas of others and nurtures innovation to make possibilities real.

Position will be hired based on level of experience.

Scientist I or Scientist II

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

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+ The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

+ We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

+ This job is eligible to participate in our short-term incentive programs. ​

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Note: No amount of pay is a considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.