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Tr1X
San Diego
Job Description Job Description Tr1X ("Trix") is a biotechnology company focused on engineering cures for autoimmune and inflammatory diseases. The company develops cellular therapies with the potential to cure disease by inducing immune tolerance and restoring homeostasis. Tr1X has a state-of-the-art technology platform that allows for the sc
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Job Source: Shelby American, Inc.Plexium Careers
San Diego, CA, United States
Plexium is a pharmaceutical company focused on developing first-in-class protein degrader therapeutics that go beyond the limitations of bivalent degraders and cereblon molecular glues. Our novel integrated drug discovery platform consists of state-of-the-art medicinal chemistry and DNA-encoded library technologies, ultra-high throughput cell-based
Job Source: Plexium CareersSan Diego, CA, United States
Position Description:
The Senior Research Associate, Discovery will work with Tr1X’s Research and Development team to design and execute in vitro and in vivo studies to characterize candidate cellular therapy products to support pipeline program advancement. This role offers exposure to company leadership, prime mentoring and scientific training, and an opportunity to be a high-impact contributor to the company’s mission and vision. The successful candidate will have technical expertise in the design, execution, and data analysis of immunological techniques including flow cytometry, ELISA, MSD, and similar methods.
The Impact You’ll Make:
Perform - primary human immune cell isolation, lentiviral transductions of primary cells, cell propagation.
Execute - assays to evaluate and characterize the function and activities of cells.
Contribute - to experimental design and method improvement/optimization.
Evaluate - various protocols in support of process development activities.
Maintain - detailed and highly organized documentation of experimental procedures and data.
Analyze - data in a timely manner and present findings at team/departmental meetings.
The Team – Yes You Belong!
We are building a diverse, bold, agile, and collaborative organization where each team member works closely and communicates respectfully with each other. Tr1X leadership has high expectations for themselves and for you (and so should you!): we expect the company and all its employees to be deeply focused on bringing Tr1X’s therapies to patients at an accelerated pace.
Key attributes to this role include attention to detail, integrity, ability to multitask and to adjustto changing priorities, and a willingness to dig in and “get things done.”
You have:
A Bachelor's degree in a relevant scientific discipline and 5+ years of experience or an MS with 2+ years of experience in immunology, cell biology or related discipline including at least 2 years working with primary human cells
Experience with cell culture for primary human cells, preferably T cells and/or Tregs.
Experience with T-cell characterization methods (flow cytometry (multiparametric andICS), cell-based assays (proliferation, cytotoxicity), ELISA, multiplex cytokine assays,
purification using MACS system, etc.).
Experience in data analysis using Graphpad Prism, Excel, and flow cytometry analysissoftware (e.g. FlowJo).
Great attention to detail and the ability to follow detailed protocols.
Agile and flexible mindset yet highly organized.
Must be able to don and wear all required Personal Protective Equipment (PPE) and tostand for long periods.
The ability to perform and excel in a start-up environment.
Optimally, you also have:
Gene editing experience.
Experience with isolation and culture of human cells from blood and blood products.
Experience with transduction of primary T-cells with retroviral or lentiviral vectors and/or AAV.
Previous cell therapy experience.
Previous experience with electronic lab notebooks (ELN).
You are:
Legally entitled to work for any employer in the US.
We offer:
In addition to a competitive compensation package with stock options, Tr1X offers comprehensive benefits for our employees and their families including medical, dental and vision insurance, 401k with generous company match and more.
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Senior Research Associate - Discovery jobs in San Diego, CA, United States
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