Senior Research Associate, Screening

San Diego, CA, United States

Plexium is a pharmaceutical company focused on developing first-in-class protein degrader therapeutics that go beyond the limitations of bivalent degraders and cereblon molecular glues. Our novel integrated drug discovery platform consists of state-of-the-art medicinal chemistry and DNA-encoded library technologies, ultra-high throughput cell-based screening, deep biological understanding of protein degradation, and extensive proteomics and informatics capabilities. Our integrated platform allows us to discover and develop novel degraders of therapeutically validated proteins for cancer and other important disease areas.

Plexium has a positive, friendly, and collaborative work environment with a culture that values teamwork, initiative, ownership and thoughtful risk-taking in developing innovative solutions to challenging scientific problems. We are committed to fostering innovation at all levels, cross-functional team collaboration, and supporting the growth and development of our team members.

Plexium’s Screening group is seeking a Senior Research Associate to join a multidisciplinary team dedicated to the discovery of novel targeted protein degradation therapeutics. The candidate must have in-depth knowledge of cell culture and experience with immunofluorescence and image-based assays. This role is hands on in developing and transitioning assays from well plates to the company’s high-throughput, high-content discovery platform and thereby providing high quality data to make actionable decisions in Biology and Chemistry.

Execute high-throughput screening campaigns

Support development of novel techniques, assays, and protocols

Ability to precisely follow protocols and gather data with a high degree of consistency

Generate and analyze high-content microscopy data

Maintain a knowledge of literature related to areas of research

Maintain up-to-date and detailed records of experiments in an electronic notebook

Required Skills and Knowledge

BS/MS degree plus 5+ years of prior laboratory experience (i.e., academic, biotech or pharmaceutical industry laboratory)

Proficiency with iPSC and neuronal cell culture

Working knowledge of immunofluorescence, western blot, and molecular biology techniques

Experience with image based assays

Exceptional attention to detail

Excellent problem-solving skills

Exemplary communication and collaboration skills, ability to work as part of a multi-disciplinary team in a fast-paced, innovative environment, delivering to project priorities and deadlines

The US base salary range for this full-time position is $85,000 - $115,000 + target annual bonus + equity + health and well-being benefits. Our salary ranges are determined by a number of factors, including but not limited to the role, location, job-related skills, and relevant education, experience and training. The range displayed on each job posting reflects the minimum and maximum target for new hire base salaries for the position across all US locations and vary by the location of the position. Our Talent Acquisition Team can share more about our salary ranges and other benefits of working at Plexium, which are not included in the posted base salary range.

Notice to third party recruitment agencies: Plexium does not accept unsolicited resumes from recruiters or employment agencies. In the absence of an executed recruitment services agreement, there will be no obligation to any referral compensation or recruiter fee.  In the event a recruiter or agency submits a resume or candidate without an agreement Plexium shall explicitly reserve the right to pursue and hire those candidate(s) without any financial obligation to the recruiter or agency. Any unsolicited resumes, including those submitted to hiring managers, shall be deemed the property of Plexium.

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