Associate Director, Modeling & Simulations (Remote)

Boston, MA, United States

Associate Director, Modeling & Simulations (Remote) page is loaded Associate Director, Modeling & Simulations (Remote) Apply locations Boston, MA time type Full time posted on Posted 4 Days Ago job requisition id REQ-21106 Job Description

General Summary:

The Associate Director, Modeling & Simulation will combine strong pharmacometric skills with deep biological understanding toindependently determine, plan, and execute M&S analyses in close collaboration with cross-functional colleagues within the R&D organization. This incumbent determines, plans, and executes technically challenging analyses b y using state of the art Modeling & Simulation methodologies to strongly contribute to critical decision making. The incumbent will lead M&S projects to evaluate study design, dose selection, probability of success estimation, portfolio strategy, pediatric extrapolation, etc. The incumbent will represent M&S with cross-functional drug development teams and clearly communicate M&S results. Finally, the incumbent will have general management duties, including possible oversight of managers and professionals, and/or management of a team(s).

Key Duties and Responsibilities:

Independently develops M&S analysis plans in alignment with an asset strategy, determines relevant outcomes, executes, and interprets multiple modeling analyses

Perform mechanism-based PKPD and population PK and PK/PD analyses, clinical trial simulations, translational modeling (preclinical – clinical) and other model-based analyses and in collaboration with other scientists on a regular basis

With significant independence, perform dataset construction, evaluation and interpretation of results, and pre- and post-processing activities including informative graphics creation

Represents M&S on cross-functional drug development teams

Serves as the M&S lead on pharmacometric deliverables for a study, including population PK, PKPD, exposure-response, model-based meta-analysis, trial simulation, etc.

Participates in preparation of regulatory responses

Knowledge and Skills:

Possess specialized, in-depth experience in M&S and excellent research record in the area of M&S, such as design and analysis of nonlinear mixed models, dynamic models, mechanistic models, adaptive designs with respect to model fitting, estimation, optimization, in particular differential equation dynamic modeling.

Deep understanding of biology, pharmacokinetic and quantitative pharmacology (PKPD) principles.

Advanced skills with the use of NONMEM PsN, R, and similar tools

Excellent collaborative, leadership, verbal and written communication skills

Education and Experience:

Master's or PhD, with preference in Pharmaceutical sciences, Pharmacometrics, mathematics, statistics, or other quantitative discipline with an emphasis on Pharmacometrics and PKPD modeling

Typically requires the following: PhD and 6 years experience or Master's Degree and 10 years of experience in the application of Pharmacometric and other Modeling methodologies in the context of drug research & development in industry, academia or regulatory agencies.

Pay Range 156,000.00 – 234,000.00 USD annually

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

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Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected].

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Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has multiple approved medicines that treat the underlying cause of cystic fibrosis (CF) — a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational small molecule, cell and genetic therapies in other serious diseases where it has deep insight into causal human biology, including sickle cell disease, beta thalassemia, APOL1-mediated kidney disease, pain, type 1 diabetes, alpha-1 antitrypsin deficiency and Duchenne muscular dystrophy.

Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia and Latin America. Vertex is consistently recognized as one of the industry's top places to work, including 13 consecutive years on Science magazine's Top Employers list and one of Fortune’s Best Workplaces in Biotechnology and Pharmaceuticals and Best Workplaces for Women. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com  or follow us on Facebook ,  Twitter ,  LinkedIn ,  YouTube  and  Instagram .

The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives.

Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.

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