Research Associate II, Gene-Edited T Cell Therapies
San Diego, CA, United States
Your Impact
The Immuno-Oncology team at Poseida is developing the next wave in gene-edited, off-the-shelf allogeneic CAR-T cells to bring potentially life-saving treatments to cancer patients in need. In this role you will use your molecular biology expertise to characterize gene edited cell therapies and increase product understanding. You will have the opportunity to work with and learn from a stellar team of scientists and research associates and together drive forward Poseida's mission to cure patients of cancer.
Position Summary
Poseida is seeking an exceptional Research Associate to join our Immuno-Oncology team. The position will utilize flow cytometry, NGS and other molecular biology techniques for rigorous molecular characterization of allogeneic CAR-T cells generated using Poseida's proprietary and highly specific Cas-CLOVER gene-editing system. This position will support the Immuno-Oncology CAR-T cell therapy pipeline as well as other gene-editing platform improvement efforts. Primary responsibilities will include designing and performing experiments, organizing and sharing data, and coordinating research projects in a highly collaborative team setting. The ideal candidate will be highly motivated, detail oriented, and possess a high level of scientific rigor.
Responsibilities
These may include but are not limited to:
Characterize gene edited CAR-T cell products using molecular biology methods including flow cytometry, next-generation sequencing (NGS) and ddPCR as well as functional cell biology methods
Support further development of Cas-CLOVER gene-edited cell therapy products
Execute routine molecular, biochemical, and cell biology laboratory techniques, including extraction of nucleic acids, PCR, qPCR, molecular cloning, Sanger sequencing, tissue culture of human cell lines and primary human cells, ELISA
Document laboratory results, analyze data and present findings (written and oral) in internal and cross-functional meetings, as required
Requirements
Requirements, Knowledge, Skills and Abilities:
Research Associate II: Master's or Bachelor's degree in a Scientific discipline with 2+ years of relevant experience.
Experience and knowledge of designing, executing, and analyzing Flow cytometry/FACS
Experience with Illumina sequencing platforms is a plus (MiSeq, NextSeq)
High proficiency in molecular biology techniques such as bacterial transformation, in vitro transcription, purification of nucleic acids, cloning, PCR, qPCR, and Sanger sequencing
Demonstrated track record in essential cell culture techniques such as maintenance of mammalian cell culture. Experience in nucleic acid transfection techniques such as electroporation, and handling primary human T/NK/B cells is a plus
Prior experience in genetic manipulation of primary human cells with CRISPR/Cas9 or other gene-editing systems (TALENs, ZFNs, etc) is a plus
Prior experience in Bioinformatics analysis of NGS data using python, R, or other programming language is a plus
Detail oriented, ability to organize, communicate, and present complex data sets to key stakeholders from diverse backgrounds
Excellent communicator with a track record of working effectively as an individual contributor and in teams
Research Associate II Pay Rate: $34.62/hour to $41.02/hour
The final pay offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience with the industry, education, geographic location, etc.
Who We Are and What We Do
Based in San Diego, Poseida Therapeutics is a clinical-stage biopharmaceutical company utilizing our unique and proprietary genetic engineering platform technologies to create next-generation cell and gene therapies with the capacity to cure. We are passionate about making an impact on patients' lives with the development of our CAR-T therapies in various cancers and gene therapies for rare diseases. Our goal is to deliver potential single treatment cures for patients in need. Our portfolio of product candidates is specifically designed to overcome the limitations of current generation cell and gene therapeutics.
At Poseida we put people first. Our team is passionate about improving patients' lives through innovation. See what our team has to say about our culture:
"My favorite part about Poseida is all the people that I get to work with. Everyone is so passionate about what we're doing here and there's so much camaraderie. It feels like one big enthusiastic family."
"My favorite part about working at Poseida is the amazing culture and working environment. Everybody is friendly, professional, collaborative, and has a remarkable can-do and positive attitude."
As we advance our compelling pipeline, there are endless opportunities for impact and growth. We encourage you to apply today!
Recruitment Fraud Alert
Alert: Beware of Employment Scams
Poseida Therapeutics, Inc. has received reports of employment-related scams. These scams have appeared in forms of false job advertisements and/or unsolicited contacts via communication/chat platforms, phone, email or text from individual(s) claiming to be or represent Poseida's Human Resources team. Be advised that Poseida Therapeutics does not extend unsolicited employment offers. Furthermore, Poseida Therapeutics does not request payment information or charge prospective employees with any fees during the recruitment process.
If you would like to pursue employment opportunities with Poseida Therapeutics, Inc., please visit our official careers website https://poseida.com/careers-culture/ or official Poseida Therapeutics LinkedIn page . Job postings that do not link directly to our careers website or official Poseida LinkedIn page are not legitimate and might be fraudulent. You may report fraudulent job advertisements or contacts via our Contact Us page at https://poseida.com/contact-us/ and select the subject "Careers." If you have been defrauded or suspect identity theft as a result of an employment scam, please contact your local law enforcement agency for guidance.
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