Senior/Staff Scientist, Bioinformatics

Berkeley, CA, United States

This is a full-time, in-person position based out of either our Berkeley, CA or New York, NY office.

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule protein sequencing platform that will transform proteomics and usher in a new era of insights into human biology and disease. To date, we have raised >$50M from venture partners and non-dilutive grant funding to achieve our vision of next generation protein sequencing.

What we are looking for in you

We are seeking an experienced bioinformatics scientist with industry experience to support Glyphic Bio's development of a next-generation protein sequencing platform. This candidate must have demonstrated success in chemical or biological science research and in data analysis and visualization. The specialist would work cross-functionally with all science teams, report to the Founding Scientist, and play an instrumental role in Glyphic's product and assay development. We value exceptional communication and organization habits, and candidates with a tendency toward systems thinking. Direct experience with SBS/ZMW/nanopore sequencing methods, next generation sequencing, and proteomics strongly preferred.

Primary Duties and Responsibilities

Establish dedicated analysis and informatics to support company milestones.

Support internal R&D projects and Product Development.

Develop, implement and troubleshoot novel analysis tools for SBS/ZMW/nanopore-based raw data and sequencing data.

Support all science teams through the development of systems for streamlined data acquisition and collaborate with colleagues to create specific analysis pipelines that address team needs.

Automate data analysis pipelines, maintain SOPs for multi-team use, and provide troubleshooting support as needed.

Maintain a centralized, shared and organized historical records of experiments conducted, problems solved, and bugs fixed.

Generate professional reports and visuals on performed data analysis, developed tools, and approaches, playing a critical role in the development of internal processes and eventual customer applications.

Required Competencies

Ph.D. or M.S. in Bioinformatics, Statistics, Computer Science, Computational Neuroscience or a related field.

For Senior Scientist: Ph.D with 4+ years of industry experience; or M.S. with 6+ years of post-graduate experience.

For Staff Scientist: Ph.D with 8+ years of industry experience; or M.S. with 12+ years of post-graduate experience.

Experience applying signal processing and signal filtering techniques to 1D/2D time-varying data. Eg. Image classification, Audio Signal Processing, digital signal from electronics etc. (Preferred experience with raw imaging data from SBS-style DNA sequencing or raw electrical signal from nanopore sequencers)

Experience using or developing machine learning and statistical methods for analyzing 1D/2D time-varying data, or sequence-based data

Visible track record of success in bioinformatics (peer-reviewed publications, patents, or significant contributions to development of commercial product).

Expertise in programming (e.g., Python, R, Perl, MATLAB, C/C++, Java) in a shared infrastructure setting (e.g., Jupyter, DeepNote)

Familiarity with Python-based machine learning frameworks and tools (eg. PyTorch, TensorFlow/Keras, Scikit-Learn)

Experience using bioinformatics tools for sequencing data and interpreting associated results

Experience with database structure, cleaning and management.

A knack for iterative process optimization and not letting perfection be the enemy of progress.

Ability to assess pain points, and identify and communicate solutions very efficiently.

Exceptional communication skills, with the ability to communicate rationale of pipeline design and clear visualization of results.

A tendency toward being hyper-organized.

Ability to work with multiple teams and maintain several projects in parallel.

Ability to work independently with limited oversight.

A commitment to maintaining the highest levels of workplace professionalism.

A willingness to self-start, embrace ambiguity and seek out opportunities for company, team, and individual improvement.

Preferred Qualifications

In-depth knowledge of current machine learning approaches

In-depth knowledge of SBS/nanopore sequencing processes and data characteristics

Physical/Cognitive Requirements

Prompt and regular attendance, punctuality, and availability to work at assigned work location, including adhering to the Department's attendance policy (e.g., adhering to your work schedule, including but not limited to: scheduled tasks, meetings, meal/rest breaks, etc.).

Ability to work shifts of at least 8 hours, 5 days per week.

Ability to work from a dedicated space that is distraction-free and has a secure, high-speed, internet connection.

Ability to thrive in a fast-paced, high-intensity work environment.

Ability to remain seated in a stationary position for prolonged periods.

Requires eye-hand coordination and manual dexterity sufficient to operate keyboard, computer, and other standard laboratory and facilities equipment.

No heavy lifting is expected, though occasional exertion of about 20 lbs. of force may be required.

Ability to interact with leadership, employees, and members in an appropriate and respectful manner.

Maintains composure during moments of stress, maintains a helpful disposition at all times, and leverages de-escalation skills and techniques when necessary.

Ability to exercise good judgment, work effectively under time constraints, prioritize work, multi-task, and adapt to changing work demands.

Not sure you meet 100% of our qualifications?

We encourage anyone who thinks they would excel at Glyphic Bio to apply, no matter their background or how they identify.

Benefits and Perks

100% Coverage for Employees & Dependents on a Comprehensive Health Plan (Medical, Dental, & Vision)

Employer Retirement Contributions // 401(k)

Employee Stock Option Plan

Flexible Paid Time Off // Vacation, Sick, & Public Holidays

Commuter Transportation Subsidy // Public Transit & Parking

Paid Maternity and Paternity Leave

Coverage for Skill Training & Development Courses

Office Workstation Stipend

Health & Wellbeing Stipend towards Gympass Access

Free Coffee and Snacks in the Office

We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

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