Scientist II/Senior Scientist, Discovery Sciences

San Francisco, CA, United States

About Rezo Therapeutics

Rezo is a different kind of biopharma company. Our mission is to dramatically increase the success rate of drug development by building a disease-agnostic, fully-integrated, network biology platform that will redefine our understanding of human disease and ability to treat it.

Our Founders and members of the Board are a group of esteemed, world-class scientists from the University of California, San Francisco: Nevan Krogan, Kevan Shokat, Sourav Bandyopadhyay, Natalia Jura, as well as renowned biotech executives George Scangos and Norbert Bischofberger. These leaders bring with them a strong track record of amazing discoveries and scientific breakthroughs, leading to very successful companies and many FDA approved drugs.

Capitalizing on our Series A of $78M from top-tier investors, we are leveraging a unique integrated approach, combining capabilities in genetics, proteomics, structural biology and AI to generate deep biological insights and novel therapeutic approaches.

Located in San Francisco’s vibrant Mission Bay neighborhood, Rezo is in close proximity to UCSF, numerous urban amenities, and outdoor recreational opportunities. We recognize that realizing our mission depends as much on our people as it does on our science and are building a workplace that fosters collaboration, respect, and diversity where contributing to your team’s success is valued as highly as individual achievements. If you’re passionate about team science and breaking down barriers to progress in drug development, please consider joining us!

The Opportunity

We are seeking a highly enthusiastic and motivated Scientist II/Senior Scientist to join our Discovery Sciences team. The ideal candidate is an expert assay biologist who thrives on rigorous experiment design and execution, contributes to various drug discovery projects and is a consummate team player. The successful candidate will be an integral member of a diverse drug discovery team, with ample opportunity to progress their career development in drug discovery. Becoming a member of this team is an excellent opportunity to join Rezo at an early stage and help build the Discovery Sciences function and contribute to various drug discovery projects.

What You'll Do: Closely interact with scientists in biology, chemistry, and other functional teams to provide in vitro assay and screening expertise for drug discovery

Develop and implement strategies to leverage medium-to high-throughput biophysical/biochemical and cellular characterization to guide SAR development

Independently design, develop, and troubleshoot experiments for small molecule discovery and characterization

Perform compound screening and MOA studies using in vitro assays and other chemical biology assay techniques

Maintain detailed records, analyze and interpret data, and generate SAR reports

Transfer optimized assays to CRO partners and manage CRO relationships to support, guide, and troubleshoot experiments

Communicate scientific findings at internal and external meetings, and via manuscripts for publication

Stay scientifically current and adopt emerging technologies to the drug discovery process

About You: PhD in chemical biology, biochemistry, cell biology, cancer biology or related discipline with 2+ years of experience in developing small molecule ligands in an industry setting

Extensive experience and in-depth knowledge of applying assay technologies (SPR, BLI, DSF, TR-FRET, AlphaLISA, NanoBRET, cell viability, etc.) to support hit discovery, characterization, and SAR development

Expert proficiency in common laboratory techniques, such as mammalian cell culture, molecular biology/cloning, PCR, Western blotting, flow cytometry, etc.

Experience with compound screening databases and data analysis/visualization software, such as CDD, Spotfire, Dotmatics, D360, etc. is a plus

Hands-on experience with mass spectrometry techniques is a plus

Experience working with molecular glue modalities is a plus

Skilled at working within a dynamic, matrixed environment with a track record of collaborating across multiple drug discovery teams

Outstanding communication, organization, and interpersonal skills

Compensation at Rezo

The expected starting salary range for this position based in San Francisco, California is $115,000-$165,000 for Scientist II and $135,000-185,000 for Senior Scientist. Actual starting salary will be determined based on multiple job-related factors including a candidate’s skills, education, and experience, the level at which they are hired, market demand, business needs, and internal parity. This role is eligible for participation in our Annual Discretionary Bonus Plan (based on individual and company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies. This position is also eligible for the benefits detailed below.

Benefits at Rezo

Medical (HMO or PPO), dental, and vision insurance

Discretionary time off policy

Company holidays (including summer and winter shutdown)

401(k) retirement savings program

Commuter / Mass Transit Benefit Program

Healthcare Flexible Spending Account (FSA)

Dependent care Flexible Spending Account (FSA)

Parental leave

Competitive compensation

Flexible work schedule

EEOC

At Rezo we value a diverse, equitable, inclusive workplace and provide equal employment opportunity to all persons without regard to race, color, sex, gender identity, gender expression, religion, age, national origin, ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. This statement covers all facets of employment and is especially important when it comes to growing our team.

If you are wondering if you’ll belong at Rezo, or are worried that you don’t meet 100% of the qualifications for this role, take a chance on us and yourself — please apply!

SF Fair Chance Ordinance

Pursuant to the San Francisco Fair Chance Ordinance, Rezo considers qualified applicants with arrest and conviction records for employment.

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