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Research Associate II

Waltham, MA, United States

This position is for a major Pharmaceutical company whose purpose is to transform the practice of medicine through breakthrough science and make a positive impact on our people and the communities we serve. Chasing the miracles of science to improve people’s lives, Join us to make a positive impact in health care!!

Required:

• Must have 3+ years of experience with LNP (novel lipid nanoparticles)

• Relevant experience in nucleic acid delivery with hands-on experience in lipid nanoparticle (LNP) formulations & characterization is a must

• Direct experience with messenger RNA encapsulation/quantification/characterization/handling is required

• RNA-related analytics (Ribogreen, gel electrophoresis, capillary electrophoresis, etc.) is required

Preferred:

• Proficiency in analytical techniques like HPLC/UPLC, DLS, CD, zeta potential, UV-Vis and fluorescence spectrophotometry etc.

• Gene Therapy and or proficiency in the above

Job Description

We are seeking a highly motivated and scientifically rigorous individual to join the Delivery and formulation development team. The position will focus on developing novel lipid nanoparticle (LNP) formulations for mRNA delivery.

Job Responsibilities

• Prepare formulations and perform characterization assays/data analysis with focus on in vivo studies, drug carrier design/development, assay development etc.

• Support vaccine formulation development activities.

• Contribute in the development & writing/reviewing analytical method protocols.

• Prepare technical reports and presentations for clear communication of scientific findings across interdisciplinary teams.

Education & Qualifications

• B.S./M.S. in Biomedical Engg/Chemistry/Physical Chemistry/Chemical Engineering/Biochemistry

• 3+ years of relevant experience in nucleic acid delivery with hands-on experience in lipid nanoparticle (LNP) formulations & characterization is a must

• Direct experience with messenger RNA encapsulation/quantification/characterization/handling is required

• Understanding and success in implementation of RNA-related analytics (Ribogreen, gel electrophoresis, capillary electrophoresis, etc.) is required

• Proficiency in analytical techniques like HPLC/UPLC, DLS, CD, zeta potential, UV-Vis and fluorescence spectrophotometry etc. is preferred

• Experience in developing LNP formulations for gene/cell immunotherapy would be advantageous

• Works collaboratively within group as well as within interdisciplinary teams

• Manages time effectively demonstrating ability to perform multiple projects at one time

• Desire to work in a fast-paced environment

• Excellent organizational and communication skills

• Strong analytical and problem-solving skills

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