Senior Director: TME Immune Portfolio Lead, ODDU

Boston, MA, United States

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Job Description Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a (Title) in our Cambridge office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law

OBJECTIVES/PURPOSE

The Oncology Drug Discovery Unit (ODDU) is seeking a dynamic leader to join as a Senior Director/Director in the Tumor Microenvironment (TME) Disruptor group, specifically as the Immune Portfolio Lead reporting to the TME Disruptor Drug Discovery Lead. The ideal candidate will possess extensive experience in drug discovery, employing a disease-first approach to unravel and target the fundamental immune mechanisms that can be exploited therapeutically to develop lead assets while nurturing a proficient scientific team. This strategic leader should be adept at contributing to projects spanning from target identification and validation to early clinical proof of concept, demonstrating a profound understanding of immuno-oncology biology, asset generation strategies, translational research, effective leadership qualities, and the capacity to offer innovative scientific insights that guide program and portfolio decisions. By proactively analyzing long-term strategies and foreseeing upcoming trends and opportunities to meet patients' unmet needs in collaboration with platform teams, this candidate will play a pivotal role in the scientific leadership team of the ODDU, overseeing peer reviews of data package plans, setting innovation priorities, establishing clear expectations for data packages to monitor progress efficiently, and addressing potential challenges. The candidate is expected to be influential across the entire drug discovery spectrum in Research (beyond Oncology). Using their enterprise mindset, the candidate will in partnership with other Research functions help to accelerate development of Takeda's discovery portfolio and in partnership with other therapeutic areas to accelerate development of Takeda’s discovery portfolio.

ACCOUNTABILITIES

The leader is expected to create, define, and effectively communicate the vision and strategy of the TME disruptor team as it relates to establishing and progressing an industry-leading research portfolio in collaboration with other Portfolio Leads across the DDU.

This leader will be responsible for leading research for selected discovery and/or development stage projects at Takeda and will work closely with Research and Development project teams, Portfolio Leads, Discovery Leads and Lab Heads to develop the strategies and to enable execution of robust, decision-enabling preclinical and translation experiments.

Prioritizes assets where deep understanding of patient segments that could benefit most to created and advance assets with modalities specifically target mechanisms responsible for altering the TME

Builds and mentors a team tailored to the vision and strategic imperatives of the ODDU.

The leader is a scientific driver for research strategy t hat brings in external innovation to supplement internal pipeline priorities in partnership with CEI (Center for External Innovation)

Oversee the work of Discovery Leads, Lab Head and team providing feedback and detailed scientific guidance and taking corrective action as needed.

Develop, drive, and execute the Research plans for selected Immune Disrupting therapeutic programs to support pre-IND packages for the DDU portfolio in partnership with Discovery Leads and Lab Head and team.

Represent ODDU within R&D and the TAU, as well as to external stakeholders with respect to the TME Disruptor programs being supported

Drive and deliver the pre-clinical development of programs and across the ODDU portfolio, leveraing resources as needed on key ODDU initiatives and assets.

Serve as an experienced thought leader for Immuno-Oncology & Translational Oncology within Takeda, guiding the research strategy and ensuring its successful execution while supporting talent development as a strong mentor and role model for emerging therapies.

Develop and deliver on the design, execution, and analysis of mechanism of action and proof-of concept studies, in close partnership across ODDU, R&D, and the TAU, including perspective across the continuum of discovery and development with a global perspective.

Support business critical decision making for pre-IND packages within the TME Disruptor pipeline, and also the broader Takeda ODDU portfolio.

Leverage up-to-date knowledge of drug development and competitive landscape at internal governance bodies as well as at key interfaces with external partners, to guide decision making.

Drive biology focus with solid translation and clinical path in partnership with Research and TAU partners.

Provide significant input into overall ODDU portfolio and department strategy

Provide direction for the identification of new targets aligned with the iDAS (integrated disease area strategy).

Provide leadership and strategic support across Research, and/or to external collaborators.

Responsible for management of resourcing and budget planning within the TME Disruptor group

Ability to work in a highly matrixed environment and establish robust connections between the biology and translational team, engaging cross-functional teams to support projects.

Work closely with in-house and external partners in developing solid translational and research plans, in interpreting results, and in determining next steps to maximize patient-centered value of the portfolio.

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

PhD in Immunology or related field with 12+ years of industry experience.

9 years of Industry experience required, and 9 years of managerial experience required.

Excellent knowledge in biologics, immunology, oncology, and drug discovery is required.

Excellent oral and written communication skills, including writing, reviewing and editing scientific documents and presenting to a range of stake-holders.

Familiarity with validation of drug targets and the exploratory drug development process. Proven biopharmaceutical industry experience developing and leading innovative therapeutic programs and advancing complex technologies.

Ability to work and drive decision-making within a multi-disciplinary, multi-regional, matrix teams with a global perspective with cultural competency.

Good fit with Takeda core values and leadership principles, including the highest personal values and ethical standards.

Right attitude (agile, curious, positive, open-minded, “can-do” mindset), must be willing and able to be “hands on,” results-oriented mindset.

Takeda’s high-engagement and ONE Research DEI culture is an important factor in our success; we seek team members who will contribute to and further strengthen that culture in all ways of working

Effective leadership, people management, communication skills, and a team builder management style are essential.

Ability to take an enterprise mindset to enable the success of Takeda.

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Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA U.S. Base Salary Range:

$205,100.00 - $322,300.00 The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained , certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based e mployee s may be eligible for s hort - t erm and/ or l ong- t erm incentive s . U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations Boston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time

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