Computational Chemist I
Boston, MA, United States
Computation is revolutionizing drug discovery. Advances in bigchemical data, massive computing power, artificial intelligence, andmolecular dynamics simulation are changing the way we develop newdrugs. At 1910 Genetics, we put computation at the heart of drugdiscovery, blending expertise in computational chemistry, structuralbiology, pharmacology, genetics, data science, and softwareengineering to develop drugs for previously undruggable targets.
You are someone we can count on to... Rollupyoursleevesas an Individual Contributor (IC)and play an important role in our mission to use AI/ML to develop drugs against historically difficult disease targets
You will own… Computational chemistryprogramsacross therapeutic modalities, disease targets, and indications
Implementation of computational chemistry toolkits (e.g.,MOE,CCDC, Cresset) to run virtual screening campaigns to rapidly identify drug candidates for further developmentwhile proactively seeking and incorporating input from Medicinal Chemistry
Effective collaboration with the Biology and Medicinal Chemistry teams by providing key computational chemistry insights to aid in theHit-to-Lead and Lead Optimization phases of drug discovery operations
Effective collaboration with the ML Engineering and AI Research team by providing key computational chemistry insights to aid in the development of AI/ML models for drug discoveryas well as the incorporation of those models into drug discovery operations
You will learn... Medicinal Chemistry
Biochemistry and biophysics
AI/ML applied to drug discovery
Existing tools, systems, and processes that currently support the 1910 Genetics team
You will teach... Key computational chemistry principles to your cross-disciplinary colleagues from Medicinal Chemistry, AI Research, Machine Learning Engineering, Cell Biology, and Pharmacology
You will improve… Our existing process for progressing from computational hit to experimental hit to lead to drug candidate
Within 1 month you will… Propose a few hundred virtual hits to the Medicinal Chemists for synthesis
Within 3 months you will… Progress a virtual hit to a biochemical/cellular hit
Co-author provisional patentson hit scaffolds
Within 6 months you will… Validate a cellular hit in a clinically relevant animal model of disease
Update provisional patents with the animal model data
Within 12 months you will… Nominate a lead candidate for progression into IND-enabling studies
Ideally, you have… Ph.D. in chemistry
2+ years ofpostdoctoralor industrialexperience
Proficiency with the Microsoft Office Suite (Excel, Word, PowerPoint, Teams), G-Suite
Extremely generous equity package coupled with competitive salary
#J-18808-Ljbffr