Senior Scientist_

Cambridge

**Why Patients Need You**

Everything we do, every day, is in line with an unwavering commitment to the quality and the delivery of safe and effective products to patients. Our science and risk-based compliant quality culture is flexible, innovative, and customer oriented. Whether you are involved in development, maintenance, compliance or analysis through research programs, your contribution will directly impact patients.

**What You Will Achieve**

The Inflammation & Immunology Research Unit (I&I RU) in Cambridge is seeking a highly motivated and innovative Senior Scientist to join the Discovery Neuroinflammation Group. This role will involve; exploration of mechanisms contributing to neuroinflammation and neurodegeneration, identification of targets for modulating neurodegenerative diseases, and building translational in vitro assays. The ideal candidate will have expertise in culturing CNS cell types, performing functional genomics in CNS relevant cell systems, and in leveraging high-parameter analysis techniques to identify and characterize cell sub-states. The candidate will work both independently and as part of multidisciplinary project teams in support portfolio projects.

**How You Will Achieve It**

+ Contribute to developing a strategy to interrogate the interplay of microglia, neurons, and astrocytes in the context of neuroinflammation and neurodegeneration.

+ Identify and prosecute the evaluation of novel therapeutic approaches to treat neurodegenerative diseases

+ Establish in vitro neuronal cell models to identify and evaluate targets using genetic and pharmacological approaches.

+ Employ a variety of molecular and cellular biology techniques, such as RNA/protein expression analysis, biochemical assays, flow cytometry, and high content/live cell imaging.

+ Define approaches to optimize and troubleshoot experimental conditions, striving for accurate modeling of the CNS environment.

+ Independently design and execute experiments, and interpret and track results. This includes being up to date on relevant literature and regular maintenance of electronic notebooks.

**Qualifications**

**Must-Have**

+ PhD in Biology, Neuroinflammation, Neuroscience or other related discipline or MS with 7+ years of relevant molecular and cellular biology experience.

+ Experience in and working knowledge of neuroinflammation, neurodegeneration.

+ Excellent communication, analytical, and critical thinking skills.

+ Ability to formulate next steps, provide recommendations, and enable data-driven decisions with a high-level of autonomy.

**PREFERRED QUALIFICATIONS**

+ Hands-on experience with culturing CNS cell types, including immortalized, primary, and iPSC-derived cells.

+ Expertise in analyzing and presenting various omics datasets

+ Experience with gene editing technologies, including CRISPR.

+ Knowledge of in vivo models of neuroinflammation and neurodegeneration to inform in vitro to in vivo translation of target biology.

+ Experience in exploring macular degeneration and retinal culture systems

+ Experience in RNA therapies and technologies

+ Preclinical pharmacology experience across diverse therapeutic modalities.

+ Publications in leading peer-reviewed journals.

+ Interest in educating and training other scientists as part of matrixed teams.

**Other Job Details:**

+ Last Date to Apply for Job: **05** **JULY 2024**

+ Eligible for referral bonus

+ Eligible for Relocation Assistance

Work Location Assignment:Flexible

Flexible colleagues are assigned a Pfizer site within a commutable distance where they work about 2-3 days weekly to connect and innovate with their team face-to-face. However, they also benefit from being able to work offsite regularly when it makes business sense to do so.

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development