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Cargo Therapeutics
San Carlos, CA, United States
Description CARGO Therapeutics is engineering best-in-class CAR T-cell therapy to overcome resistance to cancer treatment and address barriers to access so that more patients may benefit from potentially curative therapies. CARGO is on a mission to outsmart cancer by advancing a new generation of best-in-class chimeric antigen receptor (CAR) T-cel
Job Source: Cargo TherapeuticsBristol Myers Squibb
Brisbane
**Working with Us** Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that tra
Job Source: Bristol Myers SquibbGenentech
South San Francisco, CA, United States
The Position We advance science so that we all have more time with the people we love. The Senior Business Manager will support various leadership teams within the gRED Translational Medicine organization and serves as a strategic thought partner to help drive functional short-term and long-term business planning, strategy development and executi
Job Source: GenentechBigHat Biosciences
San Mateo, CA, United States
Scientist I/II, Translational Research Department: Lab Science Employment Type: Full Time Location: San Mateo, CA Description The Role: BigHat Biosciences is seeking an exceptional, self-motivated, lab-based individual to support BigHat's pipeline of novel therapeutic antibody programs. Responsibilities will include identification, validat
Job Source: BigHat BiosciencesGenentech
South San Francisco, CA, United States
The Position The Vice President, Head of Translational Medicine, Oncology is a key scientific leader and integral member of the Translational Medicine leadership team accountable forall translational research for gRED (Genentech Early Research & Development) early stage oncology portfolio and Roche's late stage oncology portfolio spanning multipl
Job Source: GenentechConfidential
South San Francisco, CA, United States
Vice President, Head of Translational Medicine, Oncology About the Company Respected biotechnology company developing innovative treatments Industry Biotechnology Type Privately Held, VC-backed Founded 1976 Employees 10,001+ Funding $200+ million Categories Biotechnology Biopharmaceuticals Biotechnology and Pharmaceuticals Pharmaceuticals Life Sci
Job Source: ConfidentialStanford Blood Center
Palo Alto, CA, United States
Fixed-term, 3 years (renewable) @ 100% FTE The Department of Emergency Medicine is seeking a Senior Research Scientist. The Senior Research Scientist will be involved directly in the execution of the Department's research activities. Emergency Medicine is a rapidly-developing field, and Stanford is leading research in many facets of care. The depar
Job Source: Stanford Blood CenterStanford University
Palo Alto, CA, United States
Fixed-term, 3 years (renewable) @ 100% FTE The Department of Emergency Medicine is seeking a Senior Research Scientist. The Senior Research Scientist will be involved directly in the execution of the Department's research activities. Emergency Medicine is a rapidly-developing field, and Stanford is leading research in many facets of care. The depar
Job Source: Stanford UniversityRedwood City, CA, United States
Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
To aid in this mission, the Translational Medicine (TM) team at RevMed is seeking a highly motivated, scientifically creative, and collaborative Senior Scientist to work in a fast-paced environment within a cross-functional team. You will be a highly motivated scientist, dedicated to biomarker discovery, clinical biomarker development, implementation, and interpretation to help advance our oncology pipeline. You will be responsible for developing and executing biomarker strategies utilizing state-of-the-art technologies for pharmacodynamic response, proof-of-mechanism, and patient stratification/selection. A strong understanding of tumor biology, molecular pathways, genomic techniques, and the ability to analyze and interpret complex data sets will be key strengths. You will have the opportunity to contribute scientifically across the portfolio to programs at various clinical development stages.
Define and execute translational and biomarker strategies for Revolution Medicine's clinical-stage oncology programs with a focus on mechanism of action, target engagement, establishment of PK/PD/efficacy relationships, patient selection strategies and understanding mechanisms of intrinsic and acquired resistance.
Ensure that clinical biomarker plans are developed and implemented efficiently and aligned with the strategic needs of the program.
Manage external biomarker analysis at contract research organizations (CROs) including experimental design, fit-for-purpose validation, budgeting, timelines, oversight of clinical implementation, and data analysis during trial conduct.
Collaborate with Translational Medicine team members in biomarker operations and clinical bioinformatics on executing biomarker plans.
Evaluate new technologies to enable exploratory biomarkers.
Represent Translational Medicine within project/program teams; analyze, interpret, and present biomarker results, meet project/program milestones for TM responsibilities.
Contribute to the development of clinical protocols, laboratory manuals, regulatory submissions, abstracts, and publications.
Effectively collaborate across internal functions including translational sciences, clinical development, clinical operations, biostatistics, data management, and clinical pharmacology to ensure successful execution in the clinic.
Required Experience, Skills, and Education:
A Ph.D. in cancer biology, cell/ molecular biology or equivalent with 3+ years of post-doctoral and/or industry experience, or an M.S. with 6+ years of industry experience. Experience in Translational Medicine with clinical-stage oncology drug development is highly desirable. Title will be commensurate with experience.
Demonstrated knowledge of clinically relevant biomarker approaches across a range of technology platforms (NGS, RNAseq, IHC, mIF, qPCR/ ddPCR, etc.), and standard analytical tools, Excel, Prism, etc
NGS and genomic biomarker data analysis experience is highly preferred.
Experience working with central laboratories and CROs supporting biomarker analysis is preferred.
Strong interpersonal and communication skills, including ability to write and present biomarker plans and results in a clear and concise manner.
A great teammate, who listens effectively and invites response and discussion.
A collaborator who communicates in an open, clear, complete, timely and consistent manner
Commitment to Revolution Medicines' Core Values: Tireless Commitment to Patients, Transformative Science, Exceptional Together, Total Integrity, Inclusiveness and Fairness
The expected salary range for this role is $150,000 - $190,000. An individual's position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.
Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact [email protected].
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Email Alert for Senior Scientist I, Translational Medicine jobs in Redwood City, CA, United States
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