Pioneering Medicines Senior Director, In Vitro Pharmacology

Cambridge, MA, United States

What if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicines is dedicated to conceiving and developing a broad portfolio of life-changing treatments by leveraging and expanding the use of Flagship's multiple bioplatforms and Flagship's proprietary innovation process. By harnessing the power of Flagship's first-in-category platforms, Pioneering Medicines creates and advances novel medicines, partnering with Flagship companies to accelerate the extension of their portfolios into new areas and show that the platform can be applied more broadly, thereby delivering benefits to more patients, sooner.

With a highly experienced drug development team and access to the wide ecosystem of Flagship companies, Pioneering Medicines is well positioned to conceive new medicine ideas both internally and in collaboration with strategic partners and advance these assets through to significant value inflection. Pioneering Medicines currently has 11 programs ongoing with plans to have more than 15 programs in 2024. Pioneering Medicines works with external strategic partners including Novo Nordisk, Pfizer, and the Cystic Fibrosis Foundation and continues to engage in discussions on potential partnerships.

Position Summary:

Pioneering Medicines is seeking a highly motivated and strategic In Vitro Pharmacology leader to support a growing portfolio of assets. This key leadership role will require an individual to direct and oversee in vitro pharmacology efforts, participating in drug discovery and early development activities. The role will involve functional accountability to support assets across a diverse range of modalities and therapeutic areas, including oncology, inflammation, and metabolic diseases. The candidate will work in cross-functional teams leading and supporting the activities, delivering research leadership, and managing/mentoring junior scientists. The successful candidate is expected to proactively build and maintain strong collaborations with Flagship Pioneering platform companies and large pharma partners. We are seeking individuals who are analytical, goal-oriented, and timeline-sensitive, while maintaining the highest of scientific and ethical standards. Strong communication skills and comfort working in a dynamic and cross-functional team environment are required.

Responsibilities:

Represent the Biology function on drug discovery project teams, supporting assets across diverse therapeutic areas/modalities including oncology, inflammation and metabolic therapeutic areas

Identify and implement preclinical models that reflect patient pathology and develop assays to support in vitro assessment of lead small molecules, antibodies, peptides and genetic modalities

Participate in partnerships and collaboration efforts with Flagship Platform companies and external pharmaceutical partners

Support research operational workstreams, such as data/compound/lab management, in collaboration with cross-functional research leaders

Management of direct report/s

This position is on-site/hybrid in Cambridge, MA

Required Qualifications & Experience

Ph.D., in Biology, Biochemistry or related field

12+ years of relevant pharmaceutical/biotechnology experience

Extensive experience in assay development and proficiency in drug discovery and development, including delivering data and documentation supporting IND/CTA regulatory filings

Proven leadership and excellent mentorship skills, with experience in managing a team and leading programmatic matrix teams

Scientific experience working in oncology, inflammation or metabolism drug discovery and development programs

Ability and interest to work across multiple therapeutic areas and modalities

Ability to effectively communicate complex scientific concepts and data to both scientific and non-scientific colleagues

Preferred Qualifications

Experience performing scientific due diligence on assets and/or platform biotechs

Experience working on cross-industry collaborations

Experience establishing processes for lab operations, including compound management

What We'll Offer You

Comprehensive, competitive healthcare and dental coverage through Blue Cross Blue Shield, vision coverage through VSP, family leave, paid flexible time off, 401k retirement plan, disability and life insurance, mental health program via Calm, backup care for children/senior and fully covered parking/commuter benefits.

A dynamic work environment with entrepreneurial spirit and highly interdisciplinary, talented, and collaborative team. Opportunities to work with Flagship scientific platforms/portfolios and create novel treatment options that benefit more patients sooner.

Professional growth opportunities through mentoring, training, immersion in cross-functional projects, and opportunities to learn and try new things.

About Flagship Pioneering:

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture. What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company's annual list of the World's Most Innovative Companies.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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