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Manifold Bio
Boston, MA, United States
Manifold Bio is a biotech company pursuing a pipeline of protein therapeutics using novel molecular measurement technologies and library-guided protein engineering. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protei
Job Source: Manifold BioFoundation Medicine, Inc.
Boston, MA, United States
Job Description About the Job The Scientist II, Computational Biology will work as part of a new product team, focused on improving blood-based cancer diagnostic capabilities in areas such as cancer detection, minimum residual disease, and other related applications. This team is comprised of talent from across the Roche ecosystem, including Roch
Job Source: Foundation Medicine, Inc.Foundation Medicine
Boston, MA, United States
About the Job The Scientist II, Computational Biology on the Computational Biology Team provides computational, bioinformatic and statistical activities to enrich the analytical capabilities of existing products as medical knowledge advances, as well as to design and build lab protocols and computational analyses for new products. Key Responsibil
Job Source: Foundation MedicineInari Agriculture, Inc.
Cambridge, MA, United States
About The Role We are looking for a Senior Computational Biologist to join our growing team and help us expand our biological data analysis and computational capabilities to better prioritize targets for genome editing in crops. The role can be based at the company headquarters in Cambridge, MA or in Ghent, Belgium As a Senior Computational Biolo
Job Source: Inari Agriculture, Inc.Sana Biotechnology
Cambridge, MA, United States
About the role The Senior Scientist, Computational Biologist will work closely with scientists and other computational biologists to analyze NGS genomics data and develop bioinformatics methods to solve exciting and challenging problems in cell and gene therapy, immunology, and stem cell biology. You will develop workflows from raw sequencing data
Job Source: Sana BiotechnologyFlagship Pioneering, Inc.
Cambridge, MA, United States
What if... you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability? Flagship Pioneering's venture creation engine has conceived and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY),
Job Source: Flagship Pioneering, Inc.Arena Bioworks
Cambridge, MA, United States
Scientist, Computational Biology and Genomics Arena BioWorks, located in Cambridge, MA, is a new biomedical research institute focused on uncovering the mechanisms of human disease to identify opportunities for therapeutic intervention. The institute's private funding model allows Arena to advance novel therapeutics by forming and supporting biot
Job Source: Arena BioworksMagnet Biomedicine
Boston, MA, United States
Scientist II/Senior Scientist, Biophysics About Magnet Biomedicine Magnet Biomedicine is a fast-paced, collaborative, venture-backed startup developing rational approaches to molecular glue discovery. Magnet's TrueGlue Discovery Platform enables the discovery and development of fit-for-purpose molecular glue strategies to target a diverse array o
Job Source: Magnet BiomedicineBoston, MA, United States
About us:
NextRNA Therapeutics, Inc. is a Boston-based biotechnology company leading the next revolution of RNA-directed therapeutics. Our focus is on identifying and drugging long non-coding RNAs (lncRNAs) with small molecules in oncology and neuroscience.
Our proprietary computational engine, combined with deep lncRNA biology expertise and strong drug discovery capabilities, positions us well to unlock the therapeutic value of lncRNAs, a vast and promising target space.
NextRNA has assembled an experienced team of industry leaders, biology and chemistry experts, and drug developers, all driven by a common passion for working together and having an impact on science and patients.
About you:
As a Scientist II/Sr. Scientist I at NextRNA Therapeutics, you will join an interdisciplinary team of highly creative and talented individuals whose vision is to improve patients’ lives by expanding the space of RNA-targeted therapies. You will have a key role in contributing to the biology efforts for one or more of our high priority programs. In this role, you will have an opportunity to work with a diverse team of biologists, biochemists, chemists and bioinformaticians to support drug discovery.
You are a rigorous scientist who takes pride in your ability to execute at the bench.
You are a real team player and collaboration is one of your best strengths.
You are conscientious, organized, and detailed oriented.
You are tenacious and thrive in a fast-paced environment and enjoy pushing the edge of what is possible.
You enjoy wearing several hats and volunteer to take on additional responsibilities for the good of the company and the team.
You possess strong written and verbal communication skills.
You adjust quickly to changing priorities and conditions and cope effectively with complexity and change.
You preserve and promote our diverse company culture by showing support and compassion to your coworkers.
What you’ll do:
Independently plan, conduct and analyze innovative and well-controlled experiments to advance our small molecules and to understand their mechanism of action.
Develop functional assays tailored to our drug discovery programs.
Maintain scientific integrity by keeping detailed and organized records of experimental protocols and results.
Communicate and present experimental outcomes effectively across the organization through oral presentations and research reports.
Work effectively in a cross-functional capacity with bioinformatics, biochemistry and chemistry teams to deliver high-quality results in an efficient manner.
Key Qualifications:
Ph.D. in Biology, Molecular Biology, Cellular Biology, Genetics, or equivalent.
3-5 years of relevant experience required, with at least 2 years in industry required.
Experience in cancer biology and early-stage oncology drug discovery process is required.
Strong foundational knowledge of RNA biology and experience with mechanism of action studies is preferred.
Proven track record of scientific innovation, as demonstrated by peer-reviewed publications or scientific presentations.
Proficiency in mammalian cell culture, common molecular biology techniques such as RNA isolation, PCR/qPCR, Western Blot, ChIP and reporter gene assays is required.
Experience with gene silencing techniques such as RNAi-mediated transient gene knockdown and/or CRISPR/Cas9 is required.
Experience with automation and other high-throughput tools and instrumentation is a plus.
Capacity for quantitative and/or statistical analysis using common software tools (e.g., GraphPad Prism, Microsoft Suite, etc.).
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Email Alert for Scientist II/Senior Scientist, Biology jobs in Boston, MA, United States
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