Director, Computational Design & In Vitro Evolution
Cambridge, MA, United States
Director, Computational Design & In Vitro Evolution page is loaded Director, Computational Design & In Vitro Evolution Apply locations Cambridge, Massachusetts Research time type Full time posted on Posted Yesterday job requisition id R15382 The Role:
Moderna Infectious Disease is seeking an exceptionally talented, highly creative, and motivated senior scientific leader with a broad skill base in computational protein design, structural informatics, in vitro evolution, and vaccine design, to lead computational antigen design within Moderna’s Antigen Design and Selection team. The Director, Computational Antigen Design and In Vitro Evolution, will be part of a highly collaborative, multi-disciplinary, and fast-paced team that is translating Moderna’s mRNA technology into an exceptionally broad portfolio of vaccines and therapeutics against infectious diseases. The Director will employ their extensive expertise in computational design, including both deep learning-based design and design specifically for nucleic acid delivery, bioinformatics, in vitro evolution, protein biochemistry and biophysics and vaccinology to lead a growing team of scientists focused on the development of novel antigens or therapeutics proteins that can be successfully encoded via Moderna’s mRNA technology. The Director will work closely with the VP, Antigen Design & Selection, the Senior Director, Structure-Guided Antigen Design, and the VP, Immunology, as well as other members of the Research, Clinical Development and Clinical Biomarker teams to advance novel candidates to the clinic, conduct exploratory trials to inform the generation of improved vaccine antigens and dissect immune responses elicited by vaccination.
This is a unique opportunity to work in an innovative environment on a truly transformative infectious diseases platform.
Here’s What You’ll Do:
Reporting to the Vice President for Antigen Design & Selection, the Director will:
Lead the computational design, bioinformatics, and in vitro evolution teams within Antigen Design & Selection, to drive the iterative optimization of vaccines and therapeutics for Moderna Infectious Disease Research
Guide team members in cutting edge computational design, informatics, and methods development including but not limited to deep learning-based methods
Guide team members to develop creative, structurally and immunologically targeted design solutions for a wide range of vaccine and therapeutic challenges
Collaborate with other members of the Moderna infectious disease research leadership team to formulate strategy for development of vaccines and therapeutics
Contribute structure-guided design and iterative optimization workflows to collaborations with other Moderna therapeutic areas for development of additional vaccines and therapeutics
Explore, test and implement innovative tools and practices that will optimize the potential of the mRNA platform for Infectious Disease Research.
Contribute to the broader scientific and platform community at Moderna Therapeutics
Contribute to the communication of R&D data for Infectious Disease Research through internal and external presentations and publications.
Identify and nurture relationships with CROs and leading academic centers with state-of-the art capabilities for protein design, characterization and
As a member of the Research Leadership team, help shape the overall portfolio of approaches and problem-solve their technical execution
Here’s What You’ll Bring to the Table:
PhD in Biochemistry, Molecular Biology, Biophysics, Computer Science, Immunology, Structural biology, or related field relevant to the role with 10 years of experience in computational protein design and informatics in Academia or industry
Extensive experience in computational protein design, structural informatics, in vitro evolution, design of vaccines and antibodies for nucleic acid delivery, computational algorithm development, protein biochemistry and biophysics, and animal studies and vaccine evaluation
Proven record of discovery of several vaccines with successful proof-of-concept studies in animal models and, ideally, in human studies
Experience in carrying projects through to IND or other equivalent early clinical milestone
Ability to effectively lead and collaborate in a dynamic, cross-functional matrixed environment.
Experience working with and overseeing partnerships with academic, industrial, governmental and other non-governmental organizations
Outstanding communication skills (verbal and written)
Ability to manage multiple projects in a fast-paced environment
Strong leadership experience, including strategy and team management
Candidate will be curious in exploring new path for drug discovery, bold in proposing creative experimental designs and ideas.
Will work collaboratively with multifunctional teams and will be relentless in pursuing successful outcomes
Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:
Highly competitive and inclusive medical, dental and vision coverage options
Flexible Spending Accounts for medical expenses and dependent care expenses
Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
Family care benefits, including subsidized back-up care options and on-demand tutoring
Free premium access to fitness, nutrition, and mindfulness classes
Exclusive preferred pricing on Peloton fitness equipment
Adoption and family-planning benefits
Dedicated care coordination support for our LGBTQ+ community
Generous paid time off, including:
• Vacation, sick time and holidays
• Volunteer time to participate within your community
• D iscretionary year-end shutdown
• Paid sabbatical after 5 years; every 3 years thereafter
Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
401k match and Financial Planning tools
Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
Complimentary concierge service including home services research, travel booking, and entertainment requests
Free parking or subsidized commuter passes
Location-specific perks and extras!
About Moderna
Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.
By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.
We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S.
If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
Moderna is a smoke-free, alcohol-free and drug-free work environment.
Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!
Moderna is proud to be an equal opportunity workplace and is an affirmative action employer.
Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is an E-Verify Employer in the United States. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements.
Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. We’re focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best.
Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the Talent Acquisition Partner or contact the Accommodations team at [email protected] . (EEO/AAP Employer)
#LI-KF1 -
About Us Our Mission and Vision
At Moderna we are pioneering the development of a new class of drugs made of messenger RNA (mRNA). This novel drug platform builds on the discovery that modified mRNA can direct the body’s cellular machinery to produce nearly any protein of interest, from native proteins to antibodies and other entirely novel protein constructs that can have therapeutic activity inside and outside of cells.
We have a clear mission to propel the field of mRNA science forward and deliver new medicines to patients and a unique vision for how to achieve this mission.
Our Mission : To deliver on the promise of transformative messenger RNA (mRNA) science to bring new medicines to patients.
Our Vision : To unlock the potential of mRNA by establishing an ecosystem of teams and partners that will work together to develop the broadest possible array of drugs, across diverse therapeutic areas and routes of administration, for serious diseases that are not treatable today.
Third Party Staffing Agencies
M oderna does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Moderna from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Moderna and do not obligate Moderna to pay fees if we hire from those resumes.
Reasonable Accommodation Notice
Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Applicants with disabilities may be entitled to reasonable accommodation under the terms of the Americans with Disabilities Act and certain state or local laws. Please inform the company's personnel representative by calling 617-460-9346 or emailing [email protected] if you need assistance completing any forms or to otherwise participate in the application process.Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.
#J-18808-Ljbffr