Scientist II/Senior Scientist, Preclinical Research

Emeryville, CA, United States

We are seeking a Scientist II/Sr. Scientist to evaluate novel genome editing systems for in vivo therapeutics as a member of our growing pre-clinical research team. Reporting to an Associate Director and Project Team Lead, the role is key to understanding the activity of our gene editing systems in therapies. This position contributes to characterization of a therapeutic target as well as the effects of gene editing in both cells and animal models. The role is highly collaborative and will impact our approach to new therapies as well as advancing current programs to clinical. This role will be based in Emeryville, California. How you’ll contribute: Edit relevant primary cells and cell lines to support lead finding and selection for pipeline programs

Perform analysis of in vitro and in vivo editing outcomes using next-generation sequencing, quantitative PCR, and RNA sequencing

Analyze the effect of gene editing and develop functional readouts employing biochemical and immunofluorescence techniques

Collaborate internally and with external partners on the optimization of non-viral delivery approaches

Utilize non-viral and viral delivery approaches to plan in vivo studies and perform various molecular analyses to support internal therapeutic programs (handling animals not required)

Independently trouble-shoot technical issues as needed

Analyze and interpret experimental data and present results at team meetings and company-wide meetings

Contribute to the selection/design of therapeutic strategies

Provide mentorship / training to research associates as appropriate

Prepare accurate and timely data summaries and contribute to writing of reports, papers, and patent manuscripts

Present at internal and external scientific meetings

What you bring: PhD in biology, biochemistry, molecular biology, gene editing, or a related discipline and at least two years of closely related gene therapy or gene editing experience OR MS degree and five years directly applicable experience

Publication record of biological discovery and/or methods development as evidenced by primary authorships in scientific journals is highly desirable.

Experience with cell culture and nucleic acid delivery techniques, quantitative PCR and/or digital droplet PCR

Experience with biochemical analysis techniques, including Western Blot, ELISA, Enzyme activity assays, Immunostaining

Experience with NGS data generation and interpretation

Extremely organized and able to efficiently manage your time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities

Ability to work independently as well as in a results-oriented team

Thrives in a fast-moving, results-oriented startup environment with critical deadlines

California Pay Transparency Disclosure:This position is classified as an exempt position under the Federal Labor Standards Act. The anticipated base salary range for this position will be $130,000 to $170,000 . You will also be eligible to receive equity, bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on location, skill level, years and depth of relevant experience, and education. About Metagenomi Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world. For more information, please visit https://metagenomi.co/.What makes Metagenomi a unique place to work? We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating disease.

We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more!

We offer competitive compensation including a market-benchmarked salary, annual target bonus, equity in an early-stage startup, and a comprehensive benefits plan, including 401(k) matching, a retirement safe harbor plan, and other perks.

At Metagenomi, we know that our people drive our success. We are an equal-opportunity employer and believe in and value diversity and inclusion. Metagenomi provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Metagenomi does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law. Please note, all candidates must be authorized to work in the United States. Applicants/Employees have rights under various State and Federal Employment Laws, includingwithout limitation: Family & Medical Leave Act

Equal Employment Opportunity Commission

Employee Polygraph Protection Act

California Family Rights Act

California Fair Employment and Housing Act

Notice to agencies: Our in-house Talent Acquisition Team manages all employment opportunities at Metagenomi. Agencies and independent recruiters must be approved as a vendor by Metagenomi’s Talent Acquisition team. To protect the interests of all parties, Metagenomi will not accept unsolicited resumes, profiles, or biographies. Any unsolicited resumes sent to Metagenomi will be considered referrals and the property of Metagenomi.

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