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Associate Director

San Francisco, CA, United States

Yoh is hiring an Associate Director - Disease Biology & Translational Sciences for our S. San Francisco, CA client.

In this role , will be responsible for helping to establish and expand the company’s capabilities for preclinical in vitro and clinical ex vivo disease pathobiology establishing in vitro/ex vivo models to interrogate complex disease models to rank and screen our therapeutic candidates, and establish the drug’s mechanism of action for multiple indications. A successful candidate for this opportunity will have a background in diabetes or obesity research.

Industry : Drug Discovery

Location : S. San Francisco, CA

Compensation : $175k - $200k (based upon experience)

Type : Direct Hire

Key Responsibilities

Design and execute in vitro and ex vivo studies to advance therapeutic programs

Lead cell based therapeutic characterization and development efforts defining the compounds mechanism of action and efficacy in complex in vitro models of disease.

Lead from the bench managing internal scientists as well as external CROs to execute strategies and be responsible for the development and conduct of in vitro , and/or ex vivo studies to support and advance company's drug discovery pipeline.

Establish pharmacodynamic and efficacy relationships as appropriate to determine the potential clinical impact of company's drugs.

Serve as the Disease Biology lead on cross-functional research and development teams and have opportunities to lead programs from discovery through early development.

Generate, analyze, and interpret complex data to establish functional PK/PD and efficacy relationships and elucidate therapeutic mechanism of action for leads drugs

Help build complex in vitro and ex vivo research and development capabilities

Author and review protocols, study reports, and regulatory documents to enable IND and other regulatory filings

Education, Skills & Experience

PhD Endocrinology, Physiology, Diabetes/Obesity, Immunology / Inflammation, or Metabolic Disease, or related biological science (MSc/BSs with relevant years of experience)

At least 8 years of direct hands-on experience in therapeutic development leveraging indication-specific functional disease models in biotechnology and pharmaceutical industries

MUST have experience with therapeutics programs that have yielded drugs entering clinical development in diabetes or obesity

Experience with cell-based assays, ELISA, MSD, qPCR, RNA-seq, microscopy, histology/pathology (e.g. IF/IHC/ISH), and/or flow cytometry

Ability to be hands-on and work in the lab, manage scientists, write protocols, execute studies leveraging company's in-house capabilities or work with CROs

Direct experimental experience with complex disease biology of diabetes, obesity or other metabolic disease

Demonstrated expertise in building PK/PD and efficacy relationships with complex 2D/3D functional cell-based and tissue-based assays

Leverage complex data sets to characterize therapeutic leads and establish a drug’s therapeutic mechanisms of action

Experience working on/leading project teams with functional responsibility to propose strategy, analyze, interpret, and present complex data to inform decisions

Ability to collaborate in writing protocols, reports, and regulatory documents

Experience working with vendors and CROs to execute studies, analyze data, and generate reports in a timely manner

Experience authoring study protocols, reports, and/or regulatory documents including IBs, IND filings, CSRs, and/or NDAs

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