Pharmacology Research Associate/Senior Research Associate
San Francisco, CA, United States
Position Summary:Seeking a Senior Research Associate for our Pharmacology and Toxicology group. This individual will play a key role in the development and execution of preclinical models to understand the efficacy and PK/PD relationships of our small molecule agents under development for the treatment of cancer.
What you’ll do:• Play a key role in evaluating mechanistic hypotheses for drug responses using samples generated from in-vivo studies, utilizing diverse molecular biology techniques to assess gene modulation and interrogate pathways of interest.• Lead the development and implementation of ex-vivo assays for screening new potential therapeutics in vivo.• Contribute to method development for new ex-vivo assays, experimental protocols, and related readouts for specific project needs.• Collaborate with research teams on relevant ex vivo assays (Western Blot, qPCR, MSD, IHC, Flow Cytometry, etc.)• Design and manage research experiments, and analyze and interpret scientific data under general supervision• Present data and report on project status at team, intra- and inter-departmental research meetings• Support general laboratory functions and organization as needed.• Document all laboratory activities, protocols, analysis methods and the collection of data.
Requirements:• BA/BS or MS with 1+ years’ (Research Associate) or 3+ years’ (Senior Research Associate) laboratory experience in cancer biology, biochemistry, cell biology, immunology or related field.• Practical laboratory experience handling and processing of animal tissues for DNA, RNA, and protein extraction.• Experience in mammalian tissue culture and ex vivo assays such as western blot, ELISA, gene expression analysis (qRT-PCR), flow cytometry, MSD, IF, and IHC.• Experience in assay development, optimization and troubleshooting is a plus.• Ability to effectively design, plan, execute, and analyze experiments under general supervision.• Efficient time management and the ability to adapt to shifting priorities and timelines.• Strong interpersonal skills and effective communication with cross function team members
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