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Tempus AI Inc.
Chicago, IL, United States
Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing
Job Source: Tempus AI Inc.The University Of Chicago
Chicago, IL, United States
Department BSD CCC - Cancer Research Lab About the Department The University of Chicago Comprehensive Cancer Center (UCCCC) is an integral component of the Biological Sciences Division (BSD). The BSD is the largest of four Divisions of the University and includes the Pritzker School of Medicine. UCCCC administers four established scientific progr
Job Source: The University Of ChicagoSociety for Pediatric and Perinatal Epidemiologic Research (SPER)
Chicago, IL, United States
The Department of Obstetrics and Gynecology at Rush University Medical Center is seeking applications for a Research Scientist who will support the Chair of the Department in the continued expansion of the OBGYN Research Program. Candidates should be passionate about conducting complex reproductive health research to decrease reproductive health di
Job Source: Society for Pediatric and Perinatal Epidemiologic Research (SPER)Wells Enterprises
Chicago
With general supervision, provides tactical execution of R&D initiatives which involves taking new and existing products from conceptualization through commercialization. Applies learnings, creativity and technical knowledge to add value through innovation. + With general supervision, coordinates project activities necessary to take new and existin
Job Source: Wells EnterprisesNorthwestern University
Chicago, IL, United States
The Department of Otolaryngology-Head and Neck Surgery at Northwestern University Feinberg School of Medicine seeks a full-time tenure track Investigator at the rank of Associate or Full Professor. Responsibilities include establishing hearing research which can effectively partner with the clinical expertise in the department present at Northweste
Job Source: Northwestern UniversityShirley Ryan AbilityLab
Chicago, IL, United States
By joining our team, you'll be part of our life-changing Mission and Vision. You'll work in a truly inclusive environment where diversity and equity are championed through words and actions. You'll contribute to an innovative culture that is second to none, one that embraces curiosity, discovery and compassion. You'll play a role in something that'
Job Source: Shirley Ryan AbilityLabVail Systems
Chicago, IL, United States
Who You Are Prosodica is seeking a Data Scientist II to help expand our Voice and Speech Analytics technology applications. In this role, your analytical skills will illuminate the potential within extensive datasets, driving significant insights that shape the future of our innovative solutions. Your work will involve meticulous data management
Job Source: Vail SystemsThe Trade Desk
Chicago, IL, United States
The Trade Desk is changing the way global brands and their agencies advertise to audiences around the world. How? With a media buying platform that helps brands deliver a more insightful and relevant ad experience for consumersand sets a new standard for global reach, accuracy, and transparency. We are proud of the culture we have built. We value t
Job Source: The Trade DeskChicago, IL, United States
Job Description Job Description Job Summary
Reporting to the Scientific Program Director, you will drive assay development, protein expression optimization, and high-throughput protein characterization for the discovery of novel protein therapeutics.
Your primary responsibility is to design and optimize assays for testing the biophysical and biochemical properties of natural and synthetic proteins. You have the expertise and experience in biomolecular structural dynamics to play a significant role on complex and challenging research projects. You’ll also be accountable for conducting experiments and analyzing and presenting data to help advance potential assets toward IND. You will collaborate with team members, data scientists, and senior leadership to meet project goals.
Location: This is an onsite role working in our Chicago office 5 days per week.
What You’ll Do
Design assays for testing biophysical and biochemical properties of natural and synthetic proteins, including expression level, solubility, stability, binding/enzymatic activity and inhibition of binding/enzymatic activity.
Lead the execution of low-throughput characterization of proteins and high-throughput plate-based/multiplexed screening assays.
Optimize protein expression, solubility, purification, and storage as needed for conducting downstream assays.
Conduct both high-throughput activity-based screening of large libraries of natural and synthetic protein sequences and low-throughput protein-characterization assays.
Collaborate with stakeholders at all levels of the organization to advance project goals.
Who You Are
You thrive in an early-stage start-up environment where you can leverage your agility and expertise to deliver high-quality results. You are naturally curious and excel when working collaboratively to solve tough problems. You are a strategic thinker and enjoy being hands-on in the lab. You have a drive for ongoing learning and development. You find satisfaction and motivation from your work, and you take the time to pursue your passions outside of the office.
Required Skills
Demonstrated expertise in biochemistry and biophysics with an emphasis on biomolecular structure and folding and function.
Proven experience in protein expression and purification using multiple types of cell lines (bacteria, mammalian, insect, yeast, etc.) and FPLC-based purification platforms such as AKTA or NGC 10.
Deep knowledge and direct working expertise in protein stability measuring techniques, binding equilibrium and kinetic measurements, and enzyme kinetics and inhibition assays.
Comfortable working with LabChip and automated liquid handling systems such as Tecan or Echo.
Familiarity with spectroscopic techniques like fluorescence, plasmonics, raman/resonance raman, EPR, NMR, and FTIR.
Proficiency with data-analysis software such as Prism, Origin, and Matlab, and structure-viewing software like PyMOL, Cn3D, Swisspdb viewer, etc.
Familiarity with interactive computing platforms like Python, R, and Jupyter.
Education + Experience:
PhD in biochemistry, biophysics, chemical biology or a related area with 4+ years of related experience; may include postdoctoral experience.
Preferred Skills
Biotech and/or pharmaceutical experience strongly preferred.
Participation in IND-enabling studies for potential therapeutics.
Hands-on experience with at least one of the following biomolecular structure determination techniques like x-ray crystallography, NMR, cryo-electron microscopy, or SAXS.
Experience with mass spectrometry techniques such as MALDI, ESI, MS-MS, LC-MS, etc.
Exposure to in silico structure prediction and structural dynamics modeling techniques like Rosetta, AlphaFold, VMD, MODELLER, and Foldit.
Please include a list of your most relevant scientific publications on your resume .
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Email Alert for Research Scientist II jobs in Chicago, IL, United States
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